Abstract

The fundamental hypothesis guiding this proposal is that plasticity in adult respiratory control can be used to enhance respiratory function in rats that had been impaired during development. Environmental conditions during development may permanently alter the structure and/or function of neural systems. Indeed, one week or one month of hyperoxia during postnatal development causes life-long attenuation of hypoxic ventilator responses in rats, an. effect unique to development. Mature animals still retain considerable capacity for different forms of respiratory plasticity. For example, chronic intermittent (CIH) and sustained (CSH) hypoxia elicits respiratory plasticity, increasing subsequent hypoxic ventilatory responses. We propose to study the capacity for ClH-induced recovery of the hypoxic ventilatory response in adult rats exposed to prenatal hyperoxIa (one week) and the mechanisms underlying this plasticity. These experiments will enhance our understanding of developmental plasticity and the expression of respiratory plasticity in functionally impaired and unimpaired animals, and may ultimately suggest new therapies for augmenting blunted chemoreflexes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HL070506-01
Application #
6487157
Study Section
Special Emphasis Panel (ZRG1-F10 (20))
Program Officer
Rothgeb, Ann E
Project Start
2002-06-01
Project End
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
1
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Biology
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Bavis, Ryan W; Johnson, Rebecca A; Ording, Kari M et al. (2006) Respiratory plasticity after perinatal hypercapnia in rats. Respir Physiol Neurobiol 153:78-91
Bisgard, Gerald E; Olson Jr, E Burt; Bavis, Ryan W et al. (2005) Carotid chemoafferent plasticity in adult rats following developmental hyperoxia. Respir Physiol Neurobiol 145:3-11
Golder, Francis J; Zabka, Andrea G; Bavis, Ryan W et al. (2005) Differences in time-dependent hypoxic phrenic responses among inbred rat strains. J Appl Physiol 98:838-44
Bavis, R W; Olson Jr, E B; Vidruk, E H et al. (2004) Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia. J Physiol 557:645-60
Bavis, R W; Olson Jr, E B; Vidruk, E H et al. (2003) Level and duration of developmental hyperoxia influence impairment of hypoxic phrenic responses in rats. J Appl Physiol 95:1550-9