The hypothesis of this application is that differential O-glycosylation of MUC-1 mucin contributes to the detachment of cancer cells from a primary cancer and mediates attachment at metastatic sites. The hypothesis will be assessed by three specific aims. The first will identify various forms of the MUC-1 mucin that interact with the matrix protein. The second specific aim will characterize the oligosaccharide and protein structure of MUC-1 mucin that interact with matrix proteins. The third specific aim will characterize the MUC-1 mucins that interact in breast cancer with normal human lung endothelial cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
National Research Service Awards for Senior Fellows (F33)
Project #
1F33CA073214-01A1
Application #
2421148
Study Section
Special Emphasis Panel (ZRG2-SSS-1 (02))
Project Start
1998-02-03
Project End
Budget Start
1997-09-01
Budget End
1997-12-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213