Since its inception in 1998, CEH has evolved as a Center of Excellence in biomedical research. It has significantly contributed to the recent designation of Jackson State University (JSU) as a high research activity institution, according to the Carnegie classification. Its long-term objective is to provide a scientific infrastructure t support research that addresses important environmental and public health issues of concern to vulnerable and underserved communities. Hence, the overarching goal of this RCMI application is the development of a more comprehensive infrastructure to strengthen the capacity to conduct environmental health and health disparities research at JSU. Toward that end, we propose the following specific aims: (1) To strengthen the capacity to conduct environmental health and health disparities research.
This aim will be addressed by recruiting and mentoring two early stage investigators who possess academic preparation and research training in cancer biology, and molecular genetics, and a research associate to assist in the biomedical research implementation; (2) To further enhance the environment for conducting cutting-edge environmental health and health disparities research. To achieve this aim we propose to: a) re-structure our multiuser core laboratories by adding a Bioinformatics component to the Biostatistical Support Unit, and upgrading the Animal, Analytical, Molecular and Cellular Biology, and Molecular Magnetic Resonance cores, b) provide access to major research instrumentation and training on the use of specialized equipment, c) implement standard operating procedures and policies, and d) monitor facilities utilization and core productivity; (3) To increase the overall research productivity of faculty. We propose to address this aim through implementation of relevant career development activities, including mentoring, scientific advising, portfolio development, granstmanship and scientific writing workshops, seminars and conferences participation, release time for biomedical research, and timely assessment of progress; (4) To foster opportunities for T1 and T2 translational research. We propose to continue to strengthen and expand CEH activities in support of intra- and inter-institutional research collaborations through formal interactions with other NIH-funded centers and programs at JSU and at other universities. We also plan to integrate CEH activities into the RTRN to increase tights with other RCMI centers, as well as other institutions of higher learning and national laboratories; (5) To increase the number of investigators conducting research in addressing environmental health and health disparities issues. We propose to develop and implement a Pilot Project Program (PPP) to provide financial support to stimulate innovative, hypothesis-driven biomedical research that will contribute to scientific advances and discoveries for the prevention and treatment of diseases associated with health disparities. Hence, the RCMI-CEH proposes to develop and implement a new plan to modernize its biomedical research infrastructure, and to establish a strong foundation for capacity building that would increase the competitiveness of JSU into mainstream environmental health and health disparities programs funded by the NIH.

Public Health Relevance

By developing the biomedical research infrastructure, the RCMI Center for Environmental Health will help Jackson State University to build a critical mass and train the new generation of biomedical scientists who will make significant contributions to scientific advances in public health and accelerate the pace of scientific discoveries on chronic diseases that is proportionately affect minorities and underserved populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12MD007581-20
Application #
9256229
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Rajapakse, Nishadi
Project Start
1998-07-01
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2019-03-31
Support Year
20
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Jackson State University
Department
Type
Schools of Arts and Sciences
DUNS #
044507085
City
Jackson
State
MS
Country
United States
Zip Code
39217
Dasari Shareena, Thabitha P; McShan, Danielle; Dasmahapatra, Asok K et al. (2018) A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health. Nanomicro Lett 10:
Mamidi, Tarun K K; Wu, Jiande; Tchounwou, Paul B et al. (2018) Whole Genome Transcriptome Analysis of the Association between Obesity and Triple-Negative Breast Cancer in Caucasian Women. Int J Environ Res Public Health 15:
Tchounwou, Paul B; Yedjou, Clement G; Udensi, Udensi K et al. (2018) State of the science review of the health effects of inorganic arsenic: Perspectives for future research. Environ Toxicol :
Yedjou, Clement G; Sims, Jennifer N; Njiki, Sylvianne et al. (2018) VERNONIA AMYGDALINA DELILE EXHIBITS A POTENTIAL FOR THE TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA. Glob J Adv Eng Technol Sci 5:1-9
Zhang, Huaisheng; Collins, Jasmine; Nyamwihura, Rogers et al. (2018) Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent. Bioorg Med Chem Lett 28:1647-1651
Carothers, Simira; Nyamwihura, Rogers; Collins, Jasmine et al. (2018) Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent. Molecules 23:
Yedjou, Clement G; Tchounwou, Solange S; Williams, Kathleen et al. (2018) NOVEL CELLULAR STAINING PROTOCOL AND ANTIPROLIFERATIVE EFFECT OF VERNONIA AMYGDALINA DELILE ON LUNG AND PROSTATE CANCER CELLS. Int J Eng Sci Res Technol 7:552-556
Kumar, Sanjay; Brown, Andrea; Tchounwou, Paul B (2018) Trisenox disrupts MDM2-DAXX-HAUSP complex and activates p53, cell cycle regulation and apoptosis in acute leukemia cells. Oncotarget 9:33138-33148
McArdle, Tanner J; Ogle, Brenda M; Noubissi, Felicite K (2018) Moving Upwards: A Simple and Flexible In Vitro Three-dimensional Invasion Assay Protocol. J Vis Exp :
Gorai, Amit Kumar; Tchounwou, Paul B; Biswal, S S et al. (2018) Spatio-Temporal Variation of Particulate Matter(PM2.5) Concentrations and Its Health Impacts in a Mega City, Delhi in India. Environ Health Insights 12:1178630218792861

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