Since its inception in 2009, Xavier University's RCIVII Center for Cancer Research has been a driving force toward achieving the University's goal of becoming a national leader in cancer and health disparities research. We propose five alms in order to move closer to attaining this goal. (1) Strengthen internal and external collaborations and partnerships, particularly those that promote health disparities and translational research: building on existing collaborations with LSU, LSU Health Sciences Center, Tulane University and the Pennington Biomedical Research Center through active partnerships in the Louisiana Cancer Research Consortium and the Louisiana Biomedical Research Network, we will leverage research and mentoring resources in place and establish new ones via partnerships formed within Xavier and between Xavier and RTRN institutions. (2) Reorganize and enhance critical core facilities: we will down size one existing core, create a new core in drug discovery and delivery and add -a bioinformatics facility to our existing Cell and Molecular Biology Core. (3) Increase Xavier's pool of competitive and productive cancer and health disparities researchers who participate in the translational research """"""""pipeline:"""""""" we will retain previously hired, now competitive, RCMI faculty, hire additional promising junior faculty in critical """"""""gap"""""""" areas that will improve our capabilities in health disparities and translational research, and provide these faculty with the resources necessary to become/remain competitive. (4)Establish a new pilot project program for cancer/health disparities research: we will use a peer-reviewed mechanism to select projects that will increase Xavier NIH R01 and other R-series grants and support pilot translational research projects for preliminary data collection. (5) Provide targeted administrative services in support of RCMI investigators: we will assure that faculty needs are met with minimal burden, research programs and core services are integrated and encourage teamwork, and that faculty development programs promote professional growth and engagement in health disparities and translational research. Successfully completing these aims will be significant because it will increase the pool of researchers who can more quickly translate bench discoveries into public benefit, particularly in minority communities. The research projects supported by the present RCMI proposal will be innovative as we propose to utilize a programmatic structure involving partnerships with major research universities, an NIH-supported Center for Minority Health and Health Disparities and an NIH-funded center for translational sciences.

Public Health Relevance

Cancer remains a major public health problem, especially among African Americans. Across the U.S., and particularly in Louisiana, the number of new cancer cases and cancer-related deaths is significantly higher in African Americans than Caucasians. Xavier's RCMI Center for Cancer Research will continue to support research to improve health outcomes for individuals with cancer, especially those from minority populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
2G12MD007595-06
Application #
8740738
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Mcclure, Shelia A
Project Start
2009-09-24
Project End
2019-03-31
Budget Start
2014-08-01
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Xavier University of Louisiana
Department
Type
University-Wide
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70125
Xu, Liang; Wang, Zhe; Chen, Xu et al. (2018) Ultrathin layered double hydroxide nanosheets with Ni(III) active species obtained by exfoliation for highly efficient ethanol electrooxidation. Electrochim Acta 260:898-904
Pham, Diana; Cormick, Gabriela; Amyx, Melissa M et al. (2018) Factors associated with postpartum depression in women from low socioeconomic level in Argentina: A hierarchical model approach. J Affect Disord 227:731-738
Toro, Tasha B; Painter, Richard G; Haynes, Rashad A et al. (2018) Purification of metal-dependent lysine deacetylases with consistently high activity. Protein Expr Purif 141:1-6
Vue, Bao; Zhang, Sheng; Vignau, Andre et al. (2018) O-Aminoalkyl-O-Trimethyl-2,3-Dehydrosilybins: Synthesis and In Vitro Effects Towards Prostate Cancer Cells. Molecules 23:
Komati, Rajesh; Mitchell, Carl A; LeBeaud, Anastasia et al. (2018) Tenacic Acids: A New Class of Tenacious Binders to Metal Oxide Surfaces. Chemistry 24:14824-14829
Yao, Xin; Gray, Selena; Pham, Tri et al. (2018) Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin. Biochem Biophys Res Commun 495:1240-1248
Toro, Tasha B; Edenfield, Samantha A; Hylton, Brandon J et al. (2018) Chelatable trace zinc causes low, irreproducible KDAC8 activity. Anal Biochem 540-541:9-14
Echeverri, Margarita; Anderson, David; Nápoles, Anna María et al. (2018) Cancer Health Literacy and Willingness to Participate in Cancer Research and Donate Bio-Specimens. Int J Environ Res Public Health 15:
Schexnayder, Chandler; Broussard, Kiera; Onuaguluchi, Demitrius et al. (2018) Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells. Int J Mol Sci 19:
Ponnapakkam, Tulasi; Saulsberry, Tyjah; Hill, Tarius et al. (2018) Inhibition of breast tumor growth in mice after treatment with ceramide analog 315. Anticancer Drugs 29:898-903

Showing the most recent 10 out of 244 publications