The """"""""decade of the brain,"""""""" an initiative intended to raise awareness aboat the nervous system in health and disease and increase participation in Drain researcti, will soon come to a close. During that period neuroscience has grown significantly, yet there are some uni'versities and colleges. that do not have a program in neuroscience teaching and research. This is particularly disturbing because neuroscience, as a life science discipline, is at the hub of biological, medicinal and pharmaceutical sciences. Institutions without a neuroscience program are mostly smaller universities and universities that serve the minority population. These university systems are aware of the critical need for training and research in neuroscience, but the difficulties in developing neuroscience programs are in part due to the lack of adequate facilities, resources and trained personnel. The goal of the application is to request funding for Agricultural and Mechanical University. The approach is to organ ize the human resources into a team and develop the infi7astructure to conduct research related to the structure, function and diseases of the nervous system.
The specific aims for a neuroscience research program include: (1) developing the physical environment, (2) engaging and supporting existing neuroscientists, and (3) recruiting additional neuroscientists. To achieve the aims, the commitments of the research participants and the host institution are imperative. The program will be engaged in multidisciplinary research, but based on the strength of the participating researchers, emphasis will be placed on research related to the aging brain and neurodegeneration. Training programs in neuroscience, at the B.S., M.S. and Ph.D. levels will eventually be developed. It is hoped that the program will be identifiable by its personnel, functions, service and its physical structure, and serve as a model research and training facility.Our resolve is to develop a competitive program that has the capacity for growth and the capability for independent existence after the RCMI support.

Project Start
1998-08-25
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Florida Agricultural and Mechanical University
Department
Type
DUNS #
City
Tallahassee
State
FL
Country
United States
Zip Code
32307
Poku, Rosemary A; Salako, Olufisayo O; Amissah, Felix et al. (2017) Polyisoprenylated cysteinyl amide inhibitors induce caspase 3/7- and 8-mediated apoptosis and inhibit migration and invasion of metastatic prostate cancer cells. Am J Cancer Res 7:1515-1527
Ntantie, Elizabeth; Fletcher, Jerrine; Amissah, Felix et al. (2017) Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer. Oncotarget 8:31726-31744
Mazzio, Elizabeth A; Soliman, Karam F A (2017) HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics 14:17-33
Godugu, Chandraiah; Doddapaneni, Ravi; Patel, Apurva R et al. (2016) Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma. Pharm Res 33:137-54
Mochona, Bereket; Jackson, Timothy; McCauley, DeCoria et al. (2016) Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs. J Heterocycl Chem 53:1871-1877
Mazzio, Elizabeth A; Li, Nan; Bauer, David et al. (2016) Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis. BMC Complement Altern Med 16:467
Etukala, Jagan R; Zhu, Xue Y; Eyunni, Suresh V K et al. (2016) Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. Bioorg Med Chem 24:3671-9
Nkembo, Augustine T; Ntantie, Elizabeth; Salako, Olufisayo O et al. (2016) The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety. Oncotarget 7:68194-68205
Boakye, Cedar H A; Patel, Ketan; Doddapaneni, Ravi et al. (2016) Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention. Colloids Surf B Biointerfaces 143:156-167
Odewumi, Caroline O; Latinwo, Lekan M; Ruden, Michael L et al. (2016) Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells. Environ Toxicol 31:1612-1619

Showing the most recent 10 out of 204 publications