Abstract

Principal aims of this project are: 1) to synthesize as many fluoro hexose nucleosides as possible as anti-AIDS agents; and 2) to evaluate these nucleosides for anti-HIV activity. In addition to azidothymidine (AZT), which inhibits the infectivity and cytopathicity of human immunodeficiency virus (HIV), two additional drugs are available. These are 2',3'-didoexy cytidine (DDC, Zalcitaline and 2',2'-didoexy inosine (DDI didanoisine). These are also reported to inhibit the infectivity and cytopathicity of HIV. These are approved by the FDA for clinical use in treating HIV infections in adults and children. Recent investigations in our laboratory have shown that unsaturated deoxy nucleosides of hexose sugar with pyrimidine bases show antiviral activity. Furthermore another unsaturated ketodeoxy fluorohgexose sugar nucleoside with 5-fluoro uracil showed moderate anti-AIDS activity in addition to in vitro anti-neoplastic property.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003020-16
Application #
6358112
Study Section
Project Start
2000-09-30
Project End
2001-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
16
Fiscal Year
2000
Total Cost
$76,369
Indirect Cost

  Institution

Name
Florida Agricultural and Mechanical University
Department
Type
DUNS #
City
Tallahassee
State
FL
Country
United States
Zip Code
32307

  Publications

Poku, Rosemary A; Salako, Olufisayo O; Amissah, Felix et al. (2017) Polyisoprenylated cysteinyl amide inhibitors induce caspase 3/7- and 8-mediated apoptosis and inhibit migration and invasion of metastatic prostate cancer cells. Am J Cancer Res 7:1515-1527
Ntantie, Elizabeth; Fletcher, Jerrine; Amissah, Felix et al. (2017) Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer. Oncotarget 8:31726-31744
Mazzio, Elizabeth A; Soliman, Karam F A (2017) HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics 14:17-33
Odewumi, Caroline O; Latinwo, Lekan M; Ruden, Michael L et al. (2016) Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells. Environ Toxicol 31:1612-1619
Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R et al. (2016) Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors. Bioorg Med Chem 24:5730-5740
Shah, Punit P; Desai, Pinaki R; Boakye, Cedar H A et al. (2016) Percutaneous delivery of ?-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis. J Drug Target 24:537-47
Mazu, Tryphon K; Bricker, Barbara A; Flores-Rozas, Hernan et al. (2016) The Mechanistic Targets of Antifungal Agents: An Overview. Mini Rev Med Chem 16:555-78
Archibong, Edikan; Foster, Alexander; Caldwell, Keirsten et al. (2016) Synthesis, characterization, and electrospinning of novel polyaniline-peptide polymers. Appl Mater Today 4:78-82
Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R et al. (2016) Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorg Med Chem 24:3464-71
Mathis, Arlesia; Rooks, Ronica; Kruger, Daniel (2016) Improving the Neighborhood Environment for Urban Older Adults: Social Context and Self-Rated Health. Int J Environ Res Public Health 13:ijerph13010003

Showing the most recent 10 out of 204 publications