This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The overall goal of the Drug Discovery Research (DDR) is to strengthen the research infra-structure for drug discovery at Florida A&M University through research collaboration in a focused and coordinated effort. Despite significant discovery of chemotherapeutic agents and their mechanisms of action, the need for new chemical entities having new mechanisms of action for the treatment of certain cancer and infectious diseases remain high. Therefore, an aggressive exploitation of new agents and their action mechanism is planned through research collaboration. Another impetus for this activity is to take a step toward a remedy for the persistent disparity in the number of minority investigators involved in drug discovery research. The difficulty in implanting drug discovery research at historically black colleges and universities is due to the lack of adequate resources, trained investigators and research infrastructure for drug discovery. To realize this goal, the DDR has developed the following five specific aims to increase drug discovery research activities in this application: enhance drug discovery research collaboration activities; establish a core analytical instrument laboratory; augment computer-based molecular modeling laboratory; increase minority investigators and support pilot research projects in the area of drug discovery. The expected outcomes of these activities are the positive impact on university research in ecumenical and increased faculty research competitiveness through collaboration and sharing of limited resources among the investigators. The University also expects an increased number of minority researchers and productivity in publishing results that lead to an increase in research funding opportunities.
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