Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aims The overall goal of this project remains the same and is to elucidate the regulatory mechanism(s) and functional consequences of cytochorme P450 (CYP) epoxygenase metabolites (EETs) in the development and progression of vascular and renal dysfunction related to diabetic metabolic syndrome. Experiments performed over the project period have resulted in significant progress on the three Specific Aims. In addition, we have expanded our recent studies to determine glomerular epithelial injury in progressive diabetic nephropathy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003034-25
Application #
8166169
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2010-06-01
Project End
2011-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
25
Fiscal Year
2010
Total Cost
$87,879
Indirect Cost

  Institution

Name
Morehouse School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310

  Publications

Piano, Ilaria; Baba, Kenkichi; Claudia Gargini et al. (2018) Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKC? in mice. Exp Eye Res 177:50-54
Owino, Sharon; Sánchez-Bretaño, Aida; Tchio, Cynthia et al. (2018) Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res 64:
Augello, Catherine J; Noll, Jessica M; Distel, Timothy J et al. (2018) Identification of novel blood biomarker panels to detect ischemic stroke in patients and their responsiveness to therapeutic intervention. Brain Res 1698:161-169
Greene, Sarah J (2018) The use and effectiveness of interactive progressive drawing in anatomy education. Anat Sci Educ 11:445-460
Chowdhury, Indrajit; Banerjee, Saswati; Driss, Adel et al. (2018) Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-?B signaling pathway. J Cell Physiol :
Huang, Ming-Bo; Gonzalez, Ruben R; Lillard, James et al. (2017) Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells. Oncotarget 8:11302-11315
Sánchez-Bretaño, Aída; Baba, Kenkichi; Janjua, Uzair et al. (2017) Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Mol Vis 23:844-852
Hu, Guoku; Yelamanchili, Sowmya; Kashanchi, Fatah et al. (2017) Proceedings of the 2017 ISEV symposium on ""HIV, NeuroHIV, drug abuse, & EVs"". J Neurovirol 23:935-940
Laurent, Virgine; Sengupta, Anamika; Sánchez-Bretaño, Aída et al. (2017) Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res 165:90-95
Chowdhury, Indrajit; Branch, Alicia; Mehrabi, Sharifeh et al. (2017) Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival. Endocrinology 158:3647-3660

Showing the most recent 10 out of 291 publications