The Center for Study of Gene Structure and Function at Hunter College will continue to focus on conducting research of high quality and recruiting minority scientists and Ph.D. candidates into this enterprise. Hunter can make a special contribution to this National undertaking. We have steadily improved our research activities; some of our laboratories are internationally recognized. Our student body is remarkably diverse, reflecting the racial and ethnic variety of New York City itself. We have recently hired more minority faculty and wish to continue this. Our request includes funds for hiring new faculty in the direct costs budget with an institutional commitment to the construction of their laboratories. Also requested are funds for minority research associates who help our research effort and diversify our staff. A major emphasis in our proposal is to reduce our dependence on RCMI funding over time. Therefore, funding of the positions for faculty and managers of core facilities is structured so that their support from the RCMI budget will be phased out in the later years of the grant. In this framework, full time salaries are requested, for different periods of time, for managers of the Biomolecular Computation and Graphics Facility, the Bio-imaging Facility, and the Mass Spectroscopy Facility. The last two are specially justified in new Research Initiatives of the Departments of Biology and Chemistry. A Biopsychology Research Initiative is also described. The Research Initiatives collectively define areas for faculty recruitment, as well as provide examples of how core facilities supply essential services. We request funds for technical support for these services which are phased out over the grant period. Supplies for these facilities are requested, in annually decreasing amounts. This new proposal contains few major requests for instrumentation. The budget is structured so that current and future institutional contributions are clearly delineated. We continue to see new sources of support outside of the RCMI program. New HIV and AIDS- related projects are presented. These comprise three areas: drug synthesis and mechanism-of-action studies, activation and control of transcription from the HIV LTR, and possible stress effects in the physiology of AIDS dementia. The Chemistry Research Initiative also has clinical - significance for HIV/AIDS in studies of pentamidine, and for cancer research (derivatives of Mitomycin C).

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Research Centers in Minority Institutions Award (G12)
Project #
Application #
Study Section
Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities (STRB)
Program Officer
Angus, C William
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Hunter College
Schools of Arts and Sciences
New York
United States
Zip Code
Luine, Victoria; Serrano, Peter; Frankfurt, Maya (2018) Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents. Horm Behav :
Avila, Jorge A; Alliger, Amber A; Carvajal, Brigett et al. (2017) Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1. Hippocampus 27:1224-1229
Gupta, Rupal; Huang, Wenlin; Francesconi, Lynn C et al. (2017) Effect of positional isomerism and vanadium substitution on 51V magic angle spinning NMR Spectra Of Wells-Dawson polyoxotungstates. Solid State Nucl Magn Reson 84:28-33
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis 1863:1157-1170
Urbanski, Mateusz M; Kingsbury, Lyle; Moussouros, Daniel et al. (2016) Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep 6:33751
Oliver, Chicora F; Kabitzke, Patricia; Serrano, Peter et al. (2016) Repeated recall and PKM? maintain fear memories in juvenile rats. Learn Mem 23:710-713
He, Huifang; Deng, Kangwen; Siddiq, Mustafa M et al. (2016) Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5. J Neurosci 36:3079-91
Carbone, Lorenzo; Verrelli, Roberta; Gobet, Mallory et al. (2016) Insight on the Li2S electrochemical process in a composite configuration electrode. New J Chem 40:2935-2943
IƱiguez, Sergio D; Aubry, Antonio; Riggs, Lace M et al. (2016) Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress 5:54-64
Babkirk, Sarah; Luehring-Jones, Peter; Dennis-Tiwary, Tracy A (2016) Computer-mediated communication preferences predict biobehavioral measures of social-emotional functioning. Soc Neurosci 11:637-51

Showing the most recent 10 out of 221 publications