This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of their close interaction and complementing infrastructures, we proposed that the Molecular Biology Core Facility and the Human Molecular Genetics Unit previously established at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) be fused into a single core facility called the Molecular Genetics Core Facility (MGCF). The goal of this facility was to enhance our institutional biomedical research capability by supporting basic and clinically oriented projects with strong molecular biology and molecular genetics components. To fulfill this goal, we proposed the following specific aims. 1. To provide the infrastructure necessary to sustain the research currently conducted in molecular genetics at the MSC especially those projects that address health disparities. 2. To increase the critical mass of research projects in molecular biology and genetics conducted at the MSC by training graduate and undergraduate students in these areas. 3. To continue to make available new methodologies in molecular genetics that can be used for analysis of the human genome by providing specialized training in molecular genetics to faculty and staff members. 4. To develop a system for genotyping and/or DNA sequencing of nucleic acids derived from humans and other sources.
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