DNA Repair in Saccharomyces - Seq Gene Sensitive to Anticancer Drug

Moore, Carol W.

Abstract

Dr. Carol Moore studies DNA repair processes and cellular radiomimetic damage in Saccharomyces cerevisiae. She is continuing her studies of mutants which show elevated genes affecting sensitivity to bleomycin have been cloned, and sequencing of one of these genes is underway. The role of these genes in cellular responses to ionizing radiation and bleomycin treatments is being investigated.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Research Centers in Minority Institutions Award (G12)
• Project #: 5G12RR003060-12
• Application #: 5224437
• Support Year: 12
• Fiscal Year: 1996

Publications

Das, Bidyut; Shi, Lingyan; Budansky, Yury et al. (2018) Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules. J Biophotonics 11:

Nicolas, Laura; Cols, Montserrat; Choi, Jee Eun et al. (2018) Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination. F1000Res 7:458

Juarez, Michelle T; Kenet, Chloe M (2018) Translating Research as an Approach to Enhance Science Engagement. Int J Environ Res Public Health 15:

Zheng, Simin; Kusnadi, Anthony; Choi, Jee Eun et al. (2018) NME proteins regulate class switch recombination. FEBS Lett :

Nicholl, Iain D; Matsui, Tsutomu; Weiss, Thomas M et al. (2018) ?-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin. Biophys J 115:642-654

Shi, Lingyan; Lu, Luyao; Harvey, George et al. (2017) Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Sci Rep 7:2599

Huang, Wenlin; Serra, Olga; Dastmalchi, Keyvan et al. (2017) Comprehensive MS and Solid-State NMR Metabolomic Profiling Reveals Molecular Variations in Native Periderms from Four Solanum tuberosum Potato Cultivars. J Agric Food Chem 65:2258-2274

Callaway, David J E; Matsui, Tsutomu; Weiss, Thomas et al. (2017) Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics. J Mol Biol 429:987-998

Patel, Joy; Lama, Lodoe; Hoffmann, Niklas A et al. (2017) RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry. Gene 612:49-54

Orlova, Natalia; Gerding, Matthew; Ivashkiv, Olha et al. (2017) The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res 45:3724-3737