This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The work of Area III Neurobiology is focused on the neural mechanisms underlying development, with special concern for how the interactions among cell types in the developing organism change the function and fate of particular cells, generally via humoral factors. Of the six members of area III, five were hired through the RCMI. All of the researchers are funded by external grants, including five of the members with R01 grants. Jay Edelman studies how cognition and sensory signals interact to create saccadic eye movement commands in humans. Jonathan Levitt uses neuroanatomical and neurophysiological methods to study the properties of single cells in visual areas of the cerebral cortex and the rules governing connections among the different regions. He is interested in how cells'responsiveness and selectivity to visual stimuli is modified by stimuli that do not by themselves evoke responses. Christine Li uses genetic methods to understand the function and regulation of a family of neuropeptide genes in the nematode Caenorhaditis elegans. She also studies a C. elegans protein related to the human amyloid precursor protein, a cleavage product of which is prevalent in the brains of Alzheimer's patients. Ofer Tchernichovski studies developmental learning in birds. On a behavioral level his lab examines how sleep affects vocal development, on a systems level his lab studies developmental changes in brain responses to auditory stimuli, and on a molecular level, his lab studies how patterns of immediate early gene expression correlate with vocal learning. Tadmiri Venkatesh studies the molecular genetic mechanisms that regulate cell cycle exit during nervous system development in Drosophila and the role of cAMP mediated signaling pathway in neuronal development and plasticity. He has recently initiated molecular genetic studies on the role of signaling pathways during the development of the mouse retina after creating Kremen-1 knockout mice while on sabatical at Stanford. Josh Wallman studies how the visual system regulates the growth of the eye. When this regulation fails eyes become nearsighted or farsighted. He imposes defocus on the developing eye by having chicks wear spectacle lenses that make them myopic or hyperopic and studies how the growth of the eye compensates, both phenomenologically and biochemically. He also studies eye movements in humans, both with respect to plasticity and the effects of attention. Area III has also continued a Neurobiology Seminar series. Our intention is to have, in addition to the seminar, a structured discussion on specific topics, prepared by having the faculty and students read papers in advance. These seminars have promoted lively conversation within the group and have led to collaborative projects with several of the visiting scientists.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Research Centers in Minority Institutions Award (G12)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
City College of New York
Schools of Arts and Sciences
New York
United States
Zip Code
Das, Bidyut; Shi, Lingyan; Budansky, Yury et al. (2018) Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules. J Biophotonics 11:
Nicolas, Laura; Cols, Montserrat; Choi, Jee Eun et al. (2018) Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination. F1000Res 7:458
Juarez, Michelle T; Kenet, Chloe M (2018) Translating Research as an Approach to Enhance Science Engagement. Int J Environ Res Public Health 15:
Zheng, Simin; Kusnadi, Anthony; Choi, Jee Eun et al. (2018) NME proteins regulate class switch recombination. FEBS Lett :
Nicholl, Iain D; Matsui, Tsutomu; Weiss, Thomas M et al. (2018) ?-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin. Biophys J 115:642-654
Akula, Hari K; Kokatla, Hariprasad; Andrei, Graciela et al. (2017) Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products. Org Biomol Chem 15:1130-1139
Khalil, Reem; Levitt, Jonathan B (2017) Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain. J Vis Exp :
Shi, Lingyan; Lindwasser, Lukas; Wang, Wubao et al. (2017) Propagation of Gaussian and Laguerre-Gaussian vortex beams through mouse brain tissue. J Biophotonics 10:1756-1760
Shi, Lingyan; Lu, Luyao; Harvey, George et al. (2017) Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Sci Rep 7:2599
Huang, Wenlin; Serra, Olga; Dastmalchi, Keyvan et al. (2017) Comprehensive MS and Solid-State NMR Metabolomic Profiling Reveals Molecular Variations in Native Periderms from Four Solanum tuberosum Potato Cultivars. J Agric Food Chem 65:2258-2274

Showing the most recent 10 out of 298 publications