Abstract

For most of Asia and the Pacific, the acquired immunodeficiency syndrome (AIDS) had not been identified prior to the late l 980s and the number of cumulative cases is still quite low (I). However, AIDS is now a public health emergency in Thailand, and many neighboring countries are also at high risk of epidemic spread of human immunodeficiency virus type (HIV-l) infection.For example, studies in Papua New Guinea (the largest and most populous of the Pacific island nations) indicate widespread high-risk sexual behaviors and high rates of sexually transmitted diseases, particularly ulcerative genital conditions. Vital baseline data are needed on the HIV-1 subtypes present in Southeast Asia and in countries, like Papua New Guinea, where health care delivery systems and high rates of syphilis and tuberculosis are comparable to those in sub-Saharan Africa. Also, the endemicity of human T-cell lymphotropic virus type I (HTLV-I) infection in some Melanesian populations in Papua New Guinea places such groups at added risk for HIV-1 infection because of the immunosuppressive and T-cell activation properties of HTLV-I.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003061-14
Application #
6205974
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Hawaii
Department
Type
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822

  Publications

Priemer, David S; Wang, Mingsheng; Zhang, Shaobo et al. (2018) Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma. Eur Urol Focus 4:880-888
Marciel, Michael P; Rose, Aaron H; Martinez, Verena et al. (2018) Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med 7:175-183
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422
Pomozi, Viola; Brampton, Christopher; Szeri, Flóra et al. (2017) Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice. J Invest Dermatol 137:595-602
Norton, Robert L; Fredericks, Gregory J; Huang, Zhi et al. (2017) Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient Fc?R-mediated phagocytosis. J Leukoc Biol 101:439-448
Baumer, Yvonne; McCurdy, Sara; Weatherby, Tina M et al. (2017) Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis. Nat Commun 8:1129
Wilcox, Christie L; Headlam, Jasmine L; Doyle, Thomas K et al. (2017) Assessing the Efficacy of First-Aid Measures in Physalia sp. Envenomation, Using Solution- and Blood Agarose-Based Models. Toxins (Basel) 9:
Yanagihara, Angel Anne; Wilcox, Christie L (2017) Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations. Toxins (Basel) 9:
Chang, Linda; Løhaugen, Gro C; Andres, Tamara et al. (2017) Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients. Ann Neurol 81:17-34
Doyle, Thomas K; Headlam, Jasmine L; Wilcox, Christie L et al. (2017) Evaluation of Cyanea capillata Sting Management Protocols Using Ex Vivo and In Vitro Envenomation Models. Toxins (Basel) 9:

Showing the most recent 10 out of 347 publications