As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Program, of the National Center for Research Resources, to further develop research excellence in biomedicine and health by establishing a translational research interdisciplinary pipeline (TRIP) aimed at linking basic sciences and clinical medicine, integrating research discoveries with innovative medical applications, and developing improved patient-care practices with community participation. Designated Research Outcomes Accelerating Discoveries for Medical Applications and Practice (ROADMAP), the UHM RCMI Program for the 2006-2011 cycle will embrace the spirit and tenets of the NIH Roadmap by creating interdisciplinary collaborative research networks employing emerging technologies for clinical and translational sciences. Specifically, the proposed research activities on biomedical imaging and bioengineering and bioactive nutrients, as well as the core facilities for tropical infectious diseases detection and prevention and for biostatistics and computer support services, will rely heavily on close interdisciplinary collaborations and intellectual exchange between basic scientists and clinicians, in applying knowledge of human biology and fundamental principles of physics, mathematics, physiology, biochemistry, molecular biology and microbiology to develop novel and improved disease-specific diagnostic tests, therapeutic interventions and preventive strategies for health disparities of regional and national importance. Moreover, these activities will be designed to closely complement the basic science, clinical and patient-oriented activities of the RCMI Clinical Research Center (RCRII) and those of other NCRR-funded initiatives, including the Pacific Research Center for Early Human Development (CCRE), Pacific Center for Emerging Infectious Diseases Research (COBRE), Cellular Basis of Immunological and Neurological Disease (INBRE), and Emotion and Cognition on Gene, Cell and Systems Levels (SNRP). The triangulation of basic science, clinical medicine and community participation will also serve to better position UHM to participate fully in the RCMI Translational Research Network (RTRN) and to ultimately secure a Clinical and Translational Sciences Award (CTSA). Strong leadership has been identified for each of the research and research-related activities. And five promising basic-science junior faculty have been paired with clinician scientists to conduct highly innovative, hypothesis-driven, interdisciplinary translational research projects that have a high likelihood of leading to independent funding. Finally, complementary technical cores are being developed and expanded to achieve greater success in competing for mainstream extramural NIH funding for research and training.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
3G12RR003061-24S2
Application #
7936701
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Douthard, Regine
Project Start
1997-09-01
Project End
2010-07-31
Budget Start
2009-09-28
Budget End
2010-07-31
Support Year
24
Fiscal Year
2009
Total Cost
$352,944
Indirect Cost
Name
University of Hawaii
Department
Type
Organized Research Units
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Priemer, David S; Wang, Mingsheng; Zhang, Shaobo et al. (2018) Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma. Eur Urol Focus 4:880-888
Marciel, Michael P; Rose, Aaron H; Martinez, Verena et al. (2018) Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med 7:175-183
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422
Yanagihara, Angel Anne; Wilcox, Christie L (2017) Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations. Toxins (Basel) 9:
Chang, Linda; Løhaugen, Gro C; Andres, Tamara et al. (2017) Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients. Ann Neurol 81:17-34
Doyle, Thomas K; Headlam, Jasmine L; Wilcox, Christie L et al. (2017) Evaluation of Cyanea capillata Sting Management Protocols Using Ex Vivo and In Vitro Envenomation Models. Toxins (Basel) 9:
Pomozi, Viola; Brampton, Christopher; van de Wetering, Koen et al. (2017) Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice. Am J Pathol 187:1258-1272
Pomozi, Viola; Brampton, Christopher; Szeri, Flóra et al. (2017) Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice. J Invest Dermatol 137:595-602
Norton, Robert L; Fredericks, Gregory J; Huang, Zhi et al. (2017) Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient Fc?R-mediated phagocytosis. J Leukoc Biol 101:439-448
Baumer, Yvonne; McCurdy, Sara; Weatherby, Tina M et al. (2017) Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis. Nat Commun 8:1129

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