This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Cell Culture and High Throughput Screening (HTS) Core Facility has vastly improved the biomedical research capabilities of this institution by providing easy access to equipment that is essential for in vitro studies of eukaryotic cells under a wide variety of conditions. Since the last review, this core facility has been expanded not only in size but also in equipment and new research capabilities. This expansion resulted in the creation of six cell culture rooms, additional cell storage capabilities, and the acquisition of cell sorting and HTS equipment. This core facility serves all the units of the BBRC and has also attracted faculty and students from various departments. The facility has also increased the number of collaborations between investigators, enhanced the training of student and staff, and has increased the productivity of the faculty. The core facility is essential for the support of research on the effects of toxicants on cells, cellular immune responses, studies on cell-pathogen interactions, and many other types of studies. This facility has recently been expanded to include a Fluorescence Activated Cell Sorter (FACS), a Flow Cytomere and a HTS Imaging Cytomer. The ability to separate cell populations by FACS will allow investigators to isolate and propagate specialized cell types and perform a wide variety of cellular assay that were not feasible in the past. The Analytical Flow Cytometer allows for the rapid analysis of populations of cells affected by a wide variety of treatments including analysis of cell death and differentiation. The HTS Imaging Cytometer incorporates confocal microscopy for the rapid analysis of high-content culture plates. Coupled with highly sophisticated imaging software, onboard incubation and a robotic plate delivery system, this multi-purpose equipment will be used to screen novel compounds and drugs with antiviral, anticancer and anti-microbial properties;thus enhancing the translational research capabilities of the BBRC. With continued RCMI funding, it is expected that these improvements in research infrastructure will result in a significant enhancement of the research capabilities of individual investigators.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Research Centers in Minority Institutions Award (G12)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas El Paso
Schools of Arts and Sciences
El Paso
United States
Zip Code
Cox, Marc B; Johnson, Jill L (2018) Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding. Methods Mol Biol 1709:397-422
Contreras, Lisett; Calderon, Ruben I; Varela-Ramirez, Armando et al. (2018) Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cell Oncol (Dordr) 41:623-636
Portillo, Frank; Branch, William R; Conradie, Werner et al. (2018) Phylogeny and biogeography of the African burrowing snake subfamily Aparallactinae (Squamata: Lamprophiidae). Mol Phylogenet Evol 127:288-303
Del Rio, Michelle; Alvarez, Juan; Mayorga, Tania et al. (2017) A comparison of arsenic exposure in young children and home water arsenic in two rural West Texas communities. BMC Public Health 17:850
Sobin, Christina; Flores-Montoya, Mayra Gisel; Alvarez, Juan Manuel (2017) Early chronic low-level Pb exposure alters global exploratory behaviors but does not impair spatial and object memory retrieval in an object-in-place task in pre-adolescent C57BL/6J mice. Neurotoxicol Teratol 61:104-114
Aranda, Gissel P; Hinojos, Samantha J; Sabandal, Paul R et al. (2017) Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor in Drosophila. Front Syst Neurosci 11:56
Montoya, Alexa; Amaya, Clarissa N; Belmont, Andres et al. (2017) Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget 8:6446-6460
Iniguez, Eva; Schocker, Nathaniel S; Subramaniam, Krishanthi et al. (2017) An ?-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major. PLoS Negl Trop Dis 11:e0006039
Zimkus, Breda M; Lawson, Lucinda P; Barej, Michael F et al. (2017) Leapfrogging into new territory: How Mascarene ridged frogs diversified across Africa and Madagascar to maintain their ecological niche. Mol Phylogenet Evol 106:254-269
Dai, Liping; Peng, Xuan-Xian; Tan, Eng M et al. (2016) Tumor-associated antigen CAPER? and microvessel density in hepatocellular carcinoma. Oncotarget 7:16985-95

Showing the most recent 10 out of 327 publications