This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project involves the design and synthesis of receptors for anions of environmental and biological importance specifically. Polyazamacrocycles as receptors and oxoanions and halides were the focus during the first year. During this time, three approaches ware employed: (i) design, synthesis, and characterization of receptors, (ii) examination of the binding capabilities of the synthesized compounds for anions in solution by NMR titration technique, and (iii) investigation of solid state structures of the host-guest complexes. A thiophene based azacryptand has been synthesized, and its anion binding properties have been studied in both solid and solution states. Crystallographic studies indicate that the ligand binds one chloride or three nitrates with an in-in conformation of the bridgehead amino protons. In the chloride complex, the encapsulated anion sits in the cavity with N++++Cl? distance 3.10(1) ?, whereas, for the nitrate complex, the three anions are located in three side pockets, and are bridged through one oxygen with the two in-in protons on the apical nitrogen with an average distance of N+++O of 3.238 ?. The NMR titrations were performed for chloride, bromide, iodide, nitrate and sulfate. Results indicated that the ligand effectively binds these anions ranging from 4,000 to 100,000 M-1. Three other ligands were also synthesized that are planed to study for anions in both solution and solid states. These compounds are currently being investigated by Dr. Clement G. Yedjou (collobaroator of this project) for cytoxicity studies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR013459-12
Application #
7959216
Study Section
Special Emphasis Panel (ZRR1-RI-1 (01))
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
12
Fiscal Year
2009
Total Cost
$128,033
Indirect Cost
Name
Jackson State University
Department
Type
Schools of Arts and Sciences
DUNS #
044507085
City
Jackson
State
MS
Country
United States
Zip Code
39217
Arslan, Zikri; Oymak, Tulay; White, Jeremy (2018) Triethylamine-assisted Mg(OH)2 coprecipitation/preconcentration for determination of trace metals and rare earth elements in seawater by inductively coupled plasma mass spectrometry (ICP-MS). Anal Chim Acta 1008:18-28
White, Jeremy; Çelik, Ahmet; Washington, Robert et al. (2018) Sequential coprecipitation and matrix removal for determination of cadmium impurities from multivitamin supplements by inductively coupled plasma mass spectrometry and method validation by isotope dilution analysis of SRM 3280 multivitamin/multielement ta Microchem J 139:242-249
Rhaman, Md Mhahabubur; Hasan, Mohammad H; Alamgir, Azmain et al. (2018) Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water. Sci Rep 8:286
Denmark, Iris S; Begu, Ermira; Arslan, Zikri et al. (2018) Removal of inorganic mercury by selective extraction and coprecipitation for determination of methylmercury in mercury-contaminated soils by chemical vapor generation inductively coupled plasma mass spectrometry (CVG-ICP-MS). Anal Chim Acta 1041:68-77
Johnson, Martha; Ates, Mehmet; Arslan, Zikri et al. (2017) Assessment of Crystal Morphology on Uptake, Particle Dissolution, and Toxicity of Nanoscale Titanium Dioxide on Artemia salina. J Nanotoxicol Nanomed 2:11-27
Portis, Bobby; Mirchi, Ali; Emami Khansari, Maryam et al. (2017) An Ideal C3-Symmetric Sulfate Complex: Molecular Recognition of Oxoanions by m-Nitrophenyl- and Pentafluorophenyl-Functionalized Hexaurea Receptors. ACS Omega 2:5840-5849
Antwi-Boasiako, Afua A; Dunn, Derrick; Dasary, Samuel S R et al. (2017) Bioconjugated graphene oxide-based Raman probe for selective identification of SKBR3 breast cancer cells. J Raman Spectrosc 48:1056-1064
Sweet, Carrie; Pramanik, Avijit; Jones, Stacy et al. (2017) Two-Photon Fluorescent Molybdenum Disulfide Dots for Targeted Prostate Cancer Imaging in the Biological II Window. ACS Omega 2:1826-1835
Kaya, Hasan; Duysak, Müge; Akbulut, Mehmet et al. (2017) Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus). Environ Toxicol 32:1213-1225
Yilmaz, Vedat; Yilmaz, Hayriye; Arslan, Zikri et al. (2017) Novel Imprinted Polymer for the Preconcentration of Cadmium with Determination by Inductively Coupled Plasma Mass Spectrometry. Anal Lett 50:482-499

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