This is a competitive renewal to provide a major source of salary support for the applicant, Mary Jeanne Kreek, M.D., as a senior Research Scientist Awardee (and also as Principal Investigator and Scientific Director of an NIH-NIDA Treatment-Related Research Center). This award will allow the applicant to continue to spend a significant amount of time in science training and mentoring at the graduate, post-graduate level, science education at the undergraduate and high school level as well as science education of a more general public. The most effective treatments for the addictive diseases including opioid addiction, cocaine addiction, alcoholism and nicotine addiction, probably will be based on the fundamental understanding of the biological basis of addictive diseases; the physiological and pharmacological effects of drugs of abuse and of agents used for the treatment of drug addiction, and of the other medical and behavioral problems which frequently co-exist with specific addictions and may complicate treatment. Also, effective treatments and prevention may by facilitated by an understanding of the human molecular genetics underlying some cases of addictive diseases. Research activities will continue to identify and study the biological correlates of addictions, factors which affect treatment outcome and also, primarily, the molecular neurological basis of addiction. Specific projects include: Effects of Drugs of Abuse and Potential Therapeutic Agents on the Molecular Biology of Endogenous Opioids, Related Neuropeptides and their Receptors; Effects of Drugs of Abuse and Potential Therapeutic Agents on Opioid Receptor and Related Neurotransmitter Systems; Disposition; Biotransformation of Natural Synthetic Opioid Agonists, Antagonist and Related Peptides; Effects of Drugs of Abuse and Potential Therapeutic Agents on the Molecular Biology and Expression of the Stress Responsive Hypothalamic Pituitary Adrenal Axis; Effects of Cocaine on Endogenous Opioid - NMDA Complex Interactions; Neuroendocrine Effects of Addictive Drugs: Role of the Endogenous Opioids and Stress Responsivity in Addictive Diseases; Effects of Drugs of Abuse and Potential Therapeutic Agents on the Molecular Biology and Expression of the Stress Responsive Hypothalamic Pituitary Adrenal Axis; Effectiveness of LAAM in Managing Heroin Abusing Methadone Maintained Patients. Human gene polymorphism and molecular genetics of addictions and the opioid system; and continued prospective surveillance of the medical status of patients entering methadone maintenance treatment, determining the changing patterns of hepatitis B, hepatitis C, HIV-1 infection and codependence and the impact of treatment on their natural history.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000049-25
Application #
6515272
Study Section
Special Emphasis Panel (ZDA1-MXS-M (06))
Program Officer
Gordon, Harold
Project Start
1978-02-01
Project End
2003-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
25
Fiscal Year
2002
Total Cost
$129,155
Indirect Cost
Name
Rockefeller University
Department
Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Zhang, Y; Brownstein, A J; Buonora, M et al. (2015) Self administration of oxycodone alters synaptic plasticity gene expression in the hippocampus differentially in male adolescent and adult mice. Neuroscience 285:34-46
Schlussman, S D; Buonora, M; Brownstein, A J et al. (2013) Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. Brain Res 1523:49-58
Lane, D A; Reed, B; Kreek, M J et al. (2011) Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction. Neuropharmacology 61:1129-40
Nielsen, David A; Ji, Fei; Yuferov, Vadim et al. (2010) Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatr Genet 20:207-14
Kreek, M J; Schlussman, S D; Reed, B et al. (2009) Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology 56 Suppl 1:32-43
Nielsen, David A; Yuferov, Vadim; Hamon, Sara et al. (2009) Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology 34:867-73
Lahita, Robert G; Schaefer, Robert A; Bradlow, H Leon et al. (2009) Clues to understanding the oxidation of estradiol in humans: effects of acute infectious hepatitis, autoimmune hepatitis, and chronic liver disease. Ann N Y Acad Sci 1155:242-51
Levran, O; Londono, D; O'Hara, K et al. (2009) Heroin addiction in African Americans: a hypothesis-driven association study. Genes Brain Behav 8:531-40
Maiya, Rajani; Zhou, Yan; Norris, Erin H et al. (2009) Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proc Natl Acad Sci U S A 106:1983-8
Reed, B; Bidlack, J M; Chait, B T et al. (2008) Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid. J Neuroendocrinol 20:606-16

Showing the most recent 10 out of 105 publications