Abstract

During the proposed renewal period, we hope to continue our past focus on novel neurotransmitters and extracellular messengers. The research design provides details regarding work on neuronal nitric oxide synthase associated proteins and D-serine. We will also pursue the inositol polyphosphates, IP7 and IP8, with a special interest in their potential to phosphorylate selected proteins. We will continue studies of heme oxygenase products, CO, iron and biliverdin-bilirubin, as well as poly(ADP-ribose) polymerase (PARP) and its role in normal cell function, as well as cell death. We will also continue our efforts characterizing neural roles of immunophilins, protein 4.1, CAIN and other cytoskeletal proteins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
2K05DA000074-21
Application #
6194827
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Pollock, Jonathan D
Project Start
1980-07-01
Project End
2005-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
21
Fiscal Year
2000
Total Cost
$124,902
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Yuan, Guoxiang; Vasavda, Chirag; Peng, Ying-Jie et al. (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8:ra37
Peng, Ying-Jie; Makarenko, Vladislav V; Nanduri, Jayasri et al. (2014) Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A 111:1174-9
Bang, Sookhee; Kim, Seyun; Dailey, Megan J et al. (2012) AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc Natl Acad Sci U S A 109:616-20
Dailey, Megan J; Kim, Seyun (2012) Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun 421:1-3
Kim, Seyun; Kim, Sangwon F; Maag, David et al. (2011) Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 13:215-21
Maag, David; Maxwell, Micah J; Hardesty, Douglas A et al. (2011) Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A 108:1391-6
Ho, Gary P H; Selvakumar, Balakrishnan; Mukai, Jun et al. (2011) S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron 71:131-41
Mustafa, Asif K; Sikka, Gautam; Gazi, Sadia K et al. (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109:1259-68
Sen, Nilkantha; Snyder, Solomon H (2010) Protein modifications involved in neurotransmitter and gasotransmitter signaling. Trends Neurosci 33:493-502
Paul, B D; Snyder, S H (2010) The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ 17:1134-40

Showing the most recent 10 out of 28 publications