During the proposed renewal period, we hope to continue our past focus on novel neurotransmitters and extracellular messengers. The research design provides details regarding work on neuronal nitric oxide synthase associated proteins and D-serine. We will also pursue the inositol polyphosphates, IP7 and IP8, with a special interest in their potential to phosphorylate selected proteins. We will continue studies of heme oxygenase products, CO, iron and biliverdin-bilirubin, as well as poly(ADP-ribose) polymerase (PARP) and its role in normal cell function, as well as cell death. We will also continue our efforts characterizing neural roles of immunophilins, protein 4.1, CAIN and other cytoskeletal proteins.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000074-22
Application #
6378233
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Pollock, Jonathan D
Project Start
1980-07-01
Project End
2005-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
22
Fiscal Year
2001
Total Cost
$125,388
Indirect Cost
Name
Johns Hopkins University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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