During the proposed renewal period, we hope to continue our past focus on novel neurotransmitters and extracellular messengers. The research design provides details regarding work on neuronal nitric oxide synthase associated proteins and D-serine. We will also pursue the inositol polyphosphates, IP7 and IP8, with a special interest in their potential to phosphorylate selected proteins. We will continue studies of heme oxygenase products, CO, iron and biliverdin-bilirubin, as well as poly(ADP-ribose) polymerase (PARP) and its role in normal cell function, as well as cell death. We will also continue our efforts characterizing neural roles of immunophilins, protein 4.1, CAIN and other cytoskeletal proteins.
| Yuan, Guoxiang; Vasavda, Chirag; Peng, Ying-Jie et al. (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8:ra37 |
| Peng, Ying-Jie; Makarenko, Vladislav V; Nanduri, Jayasri et al. (2014) Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A 111:1174-9 |
| Bang, Sookhee; Kim, Seyun; Dailey, Megan J et al. (2012) AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc Natl Acad Sci U S A 109:616-20 |
| Dailey, Megan J; Kim, Seyun (2012) Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun 421:1-3 |
| Kim, Seyun; Kim, Sangwon F; Maag, David et al. (2011) Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 13:215-21 |
| Maag, David; Maxwell, Micah J; Hardesty, Douglas A et al. (2011) Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A 108:1391-6 |
| Ho, Gary P H; Selvakumar, Balakrishnan; Mukai, Jun et al. (2011) S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron 71:131-41 |
| Mustafa, Asif K; Sikka, Gautam; Gazi, Sadia K et al. (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109:1259-68 |
| Subramaniam, Srinivasa; Mealer, Robert G; Sixt, Katherine M et al. (2010) Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. J Biol Chem 285:20428-32 |
| Peng, Ying-Jie; Nanduri, Jayasri; Raghuraman, Gayatri et al. (2010) H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A 107:10719-24 |
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