The applicant will conduct research projects of three types: a. clinical trials to assess the efficacy of promising psychosocial interventions, b. projects to improve methods of classifying substance abusers with the particular aim of defining clinically meaningful subgroups and c. family/genetic studies assessing rates and patterns of substance use disorders and psychopathology in the relatives of substance abusers. The Research Plan provides a detailed description of a project aimed at a promising area in the diagnosis of drug abusers: psychiatric comorbidity, specifically DSM-III-R/DSM-IV Axis II (Personality) disorders. In this renewal study we will 1. Extend data analyses from the first study period, particularly in the areas of characterizing drug use severity and screening for drug abuse, 2. Give a comprehensive battery of assessments to determine rates of Personality Disorders and their clinical correlates in a. a variety of clinical samples of substance abusers and b. demographically matched community controls, 3. Assess several aspects of reliability and validity of differing systems and methods for diagnosing Personality Disorders/Dimensions in substance abusers, 4. Apply and evaluate methods to enhance the reliability and validity of existing instruments for diagnosing Personality Disorders/Dimensions in substance abusers, and 5. Evaluate the associations among different Personality Disorders in substance abusers and seek underlying dimensions of personality pathology in this special population.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Award (K05)
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Application #
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
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Yale University
Schools of Medicine
New Haven
United States
Zip Code
Samuel, Douglas B; Carroll, Kathleen M; Rounsaville, Bruce J et al. (2013) Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. J Pers Disord 27:625-35
Worhunsky, Patrick D; Stevens, Michael C; Carroll, Kathleen M et al. (2013) Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome. Psychol Addict Behav 27:477-88
DeVito, Elise E; Worhunsky, Patrick D; Carroll, Kathleen M et al. (2012) A preliminary study of the neural effects of behavioral therapy for substance use disorders. Drug Alcohol Depend 122:228-35
Gueorguieva, Ralitza; Wu, Ran; Donovan, Dennis et al. (2012) Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinking outcomes during treatment. Alcohol 46:121-31
Kiluk, Brian D; Nich, Charla; Carroll, Kathleen M (2011) Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. Drug Alcohol Depend 114:169-76
Gueorguieva, Ralitza; Wu, Ran; Donovan, Dennis et al. (2011) Baseline trajectories of drinking moderate acamprosate and naltrexone effects in the COMBINE study. Alcohol Clin Exp Res 35:523-31
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Carroll, Kathleen M; Kiluk, Brian D; Nich, Charla et al. (2011) Cognitive function and treatment response in a randomized clinical trial of computer-based training in cognitive-behavioral therapy. Subst Use Misuse 46:23-34
Franco, Christine A; Maciejewski, Paul K; Potenza, Marc N (2011) Past-year recreational gambling in a nationally representative sample: correlates of casino, non-casino, and both casino/non-casino gambling. Psychiatry Res 188:269-75
Brewer, Judson A; Mallik, Sarah; Babuscio, Theresa A et al. (2011) Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug Alcohol Depend 119:72-80

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