The major goals are to continue and extend research on: (1) risk and protective factors involved in onset, stability and change in adolescent drug use; (2) testing pathways to drug use; (3) interactive effects of risk and protective factors; and (4) consequences of drug use on adolescent and young adult functioning. The proposed research will expand on and extend prior research by: (1) inclusions of samples of inner city youngsters and IV drug abusers; (2) comparisons of the etiologies of drug use, delinquency, psychopathology, and sexual precocity; (3) study of intra- and intergenerational transmission of drug-prone characteristics; and (4) examination of factors related to AIDS transmission behavior and to coping with AIDS. In order to achieve these goals, an integrated program of research is underway involving four large-scale projects: I. A longitudinal study of approximately 1000 children and their mothers seen at four points in time from ages 1-10 to 15-24; II. A multigenerational study of 250 two-year old offspring of the original study child in Project I; III. A study of about 1600 inner city Black and Puerto Rican adolescents (including a school drop-out sample); IVA. A study of 400 male HIV+ and HIV- intravenous drug users; and IVB. A study of 400 female HIV+ and HIV- intravenous drug users. The major significance of this program of integrated research is that it addresses many critical issues in the drug field, e.g., what can protect against these risks; how do risk and protective factors operate in populations most likely to become involved in drug or other problem behaviors, including those implicated in the spread of AIDS; how can one break the transmission of the risk from one generation to the next; and how can the consequences of drug use be averted or lessened.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Award (K05)
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Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Program Officer
Normand, Jacques
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Mount Sinai School of Medicine
Public Health & Prev Medicine
Schools of Medicine
New York
United States
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Morojele, Neo K; Brook, Judith S; Brook, David W (2016) Tobacco and alcohol use among adolescents in South Africa: shared and unshared risks. J Child Adolesc Ment Health 28:139-52
Pahl, Kerstin; Brook, Judith S; Zhang, Chenshu et al. (2016) Psychosocial Predictors of Mental Health Service Utilization Among Women During their Mid-Sixties. J Behav Health Serv Res 43:143-54
Brook, Judith S; Zhang, Chenshu; Rubenstone, Elizabeth et al. (2016) Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. Addict Behav 62:114-21
Brook, Judith S; Zhang, Chenshu; Brook, David W et al. (2015) Compulsive buying: Earlier illicit drug use, impulse buying, depression, and adult ADHD symptoms. Psychiatry Res 228:312-7
Lee, Jung Yeon; Brook, Judith S; Finch, Stephen J et al. (2015) Trajectories of marijuana use from adolescence to adulthood predicting unemployment in the mid 30s. Am J Addict 24:452-9
Brook, David W; Lee, Jung Yeon; Morojele, Neo K et al. (2015) Predictors of Childhood Depressed Mood: A Two-Generational Study. J Child Fam Stud 24:2786-2794
Brook, Judith S; Balka, Elinor B; Zhang, Chenshu et al. (2015) Intergenerational Transmission of Externalizing Behavior. J Child Fam Stud 24:2957-2965
Brook, Judith S; Zhang, Chenshu; Rubenstone, Elizabeth et al. (2015) Insomnia in adults: the impact of earlier cigarette smoking from adolescence to adulthood. J Addict Med 9:40-5
Brook, Judith S; Lee, Jung Yeon; Brook, David W (2015) Trajectories of Marijuana Use Beginning in Adolescence Predict Tobacco Dependence in Adulthood. Subst Abus 36:470-7
Brook, Judith S; Lee, Jung Yeon; Rubenstone, Elizabeth et al. (2014) Triple comorbid trajectories of tobacco, alcohol, and marijuana use as predictors of antisocial personality disorder and generalized anxiety disorder among urban adults. Am J Public Health 104:1413-20

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