The goal of this application for the renewal of a Research Scientist Award is to discover how chronic conduct problems develop in childhood and adolescence and how serious conduct disorder can be prevented. The PI proposes three programs of research and a plan for professional development.
The aim of the first program (funded by NICHD) is to understand basic cognitive and emotional processes in aggressive behavior. It is hypothesized that acquired knowledge structures stored in memory guide an individual's processing of social information, leading to individual differences in behavior. Processing occurs in sequential steps of encoding, interpretation, response generation, response evaluation, and enactment. These processes will be related to aggressive behavior patterns over time in a sample of 259 adolescent boys and girls (40 percent African-American).
The aim of the second program (funded by NICHD) is to build a transactional ecosymbiotic model of the development of chronic conduct problems in adolescence. Biological disposition, sociocultural context, and life experience risk factors are hypothesized to lead to conduct problems in additive, interactive, mediational, and reciprocally influential ways. All factors are hypothesized to be mediated by proximal cognitive and emotional processes. The model will be tested in an ongoing longitudinal sample of 585 boys and girls (20 percent African-American) who have been followed since preschool and will reach age 19 during this 5-year period.
The aim of the third program (called FAST Track and funded by NIMH) is to create, implement, and evaluate a comprehensive intervention designed to prevent the development of serious conduct disorder in high-risk children. After screening 11,000 kindergarten boys and girls in four geographic sites and three cohorts, 960 children (75 percent boys; 50 percent African-American) were selected as high-risk and randomly assigned to receive intervention or serve as controls. Children will enter high school by the end of the next 5-year period. Analyses will focus on intervention efficacy, predictors of intervention success, process-to-outcome relations, and cost-benefit ratios. The PI's research mentoring includes directing an NIMH-supported training program in developmental psychopathology and prevention research. The PI's professional development plans include advanced training in statistics, psychophysiology, cultural awareness and impact, and prevention policy analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH001027-09
Application #
2889802
Study Section
Child/Adolescent Risk and Prevention Review Committee (CAPR)
Program Officer
Pearson, Jane L
Project Start
1992-09-01
Project End
2002-04-30
Budget Start
1999-08-19
Budget End
2000-04-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Anderson, Sarah L; Zheng, Yao; McMahon, Robert J (2018) Do Callous-Unemotional Traits and Conduct Disorder Symptoms Predict the Onset and Development of Adolescent Substance Use? Child Psychiatry Hum Dev 49:688-698
Sorensen, Lucy C; Dodge, Kenneth A; Conduct Problems Prevention Research Group (2016) How Does the Fast Track Intervention Prevent Adverse Outcomes in Young Adulthood? Child Dev 87:429-45
Hanson, Jamie L; Albert, Dustin; Iselin, Anne-Marie R et al. (2016) Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood. Soc Cogn Affect Neurosci 11:405-12
Pasalich, Dave S; Witkiewitz, Katie; McMahon, Robert J et al. (2016) Indirect Effects of the Fast Track Intervention on Conduct Disorder Symptoms and Callous-Unemotional Traits: Distinct Pathways Involving Discipline and Warmth. J Abnorm Child Psychol 44:587-97
Sasser, Tyler R; Kalvin, Carla B; Bierman, Karen L (2016) Developmental trajectories of clinically significant attention-deficit/hyperactivity disorder (ADHD) symptoms from grade 3 through 12 in a high-risk sample: Predictors and outcomes. J Abnorm Psychol 125:207-219
Okado, Yuko; Bierman, Karen L (2015) Differential risk for late adolescent conduct problems and mood dysregulation among children with early externalizing behavior problems. J Abnorm Child Psychol 43:735-47
Albert, Dustin; Belsky, Daniel W; Crowley, D Max et al. (2015) Developmental mediation of genetic variation in response to the Fast Track prevention program. Dev Psychopathol 27:81-95
Dodge, Kenneth A; Bierman, Karen L; Coie, John D et al. (2015) Impact of early intervention on psychopathology, crime, and well-being at age 25. Am J Psychiatry 172:59-70
Jones, Damon E; Greenberg, Mark; Crowley, Max (2015) Early Social-Emotional Functioning and Public Health: The Relationship Between Kindergarten Social Competence and Future Wellness. Am J Public Health 105:2283-90
Albert, Dustin; Belsky, Daniel W; Crowley, D Max et al. (2015) Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial. J Policy Anal Manage 34:497-518

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