That sleep is important for health is indicated by recent studies from this laboratory. Rats subjected to chronic total sleep deprivation or paradoxical (REM) sleep deprivation showed debilitated appearance, skin lesions on the paws and tail, decreased body temperature, increased energy expenditure, decreased serum thyroxine, increased serum norepinephrine, and eventual death. The research proposed below is oriented toward clarifying and elaborating upon these results. 1. To evaluate whether impaired heat retention is the """"""""core"""""""" pathology in sleep deprived rats, we will determine whether sleep deprived rats self-select warm temperatures. Also we will determine whether deprivation-induced pathology is exacerbated in a cold ambient environment. 2. To evaluate whether the core pathology is mediated by sympathetic activation, we will determine whether the effects of sleep deprivation are blunted by maintaining rats on guanethidine, which blocks transmission at postganglionic sympathetic terminals. 3. To evaluate whether the core pathology is an increased metabolic rate, we will determine whether deprivation-induced pathology is blunted by a prior thyroidectomy. 4. We propose to complete studies on the reversibility of pathology induced by sleep deprivation. 5. To evaluate whether the increase in energy expenditure is mediated by the presence of an unidentified blood borne substance, we will circulate the blood of a deprived rat through a recipient rat while the metabolic rate of the recipient rat's intestine is monitored on-line 6. We proposed to evaluate the effects of sleep deprivation on immune function, mitosis, and cell structure.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH018428-24
Application #
3076024
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1977-09-01
Project End
1992-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
24
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Bergmann, B M; Gilliland, M A; Feng, P F et al. (1996) Are physiological effects of sleep deprivation in the rat mediated by bacterial invasion? Sleep 19:554-62
Feng, P F; Shaw, P; Bergmann, B M et al. (1995) Sleep deprivation in the rat: XX. Differences in wake and sleep temperatures during recovery. Sleep 18:797-804
Bergmann, B M; Seiden, L S; Landis, C A et al. (1994) Sleep deprivation in the rat: XVIII. Regional brain levels of monoamines and their metabolites. Sleep 17:583-9
Bergmann, B M; Landis, C A; Zenko, C E et al. (1993) Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature. Sleep 16:221-5
Tsai, L L; Bergmann, B M; Rechtschaffen, A (1992) Sleep deprivation in the rat: XVI. Effects in a light-dark cycle. Sleep 15:537-44
Landis, C A; Bergmann, B M; Ismail, M M et al. (1992) Sleep deprivation in the rat: XV. Ambient temperature choice in paradoxical sleep-deprived rats. Sleep 15:13-20
Prete, F R; Bergmann, B M; Holtzman, P et al. (1991) Sleep deprivation in the rat: XII. Effect on ambient temperature choice. Sleep 14:109-15
Pilcher, J J; Bergmann, B M; Refetoff, S et al. (1991) Sleep deprivation in the rat: XIII. The effect of hypothyroidism on sleep deprivation symptoms. Sleep 14:201-10
Benca, R M; Bergmann, B M; Leung, C et al. (1991) Rat strain differences in response to dark pulse triggering of paradoxical sleep. Physiol Behav 49:83-7
Obermeyer, W; Bergmann, B M; Rechtschaffen, A (1991) Sleep deprivation in the rat: XIV. Comparison of waking hypothalamic and peritoneal temperatures. Sleep 14:285-93

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