The initial objectives of our Physician Scientist Program are to provide physicians who have completed some housestaff training with a broad background in basic biomedical research as well as direct laboratory experience supervised by a basic scientist. In addition, each year two medical students will be supported to carry out a full year of basic laboratory research during a leave of abscence from the regular medical school curriculum. During Phase I of their training Physician Scientists will be enrolled in formal courses and begin laboratory work in a basic science area. All trainees will take the graduate course in Biochemistry and Molecular Biology. The selection of other course work will depend on the previous scientific background and specific research interests of each Physician Scientist. Such courses might include didactic or seminar courses taught by the faculty of the various basic science departments at the School of Medicine of subjects such as advanced chemistry, physics, or mathematics at the undergraduate campus of the University. Criteria for the choice of basic science sponsors include a stimulating laboratory environment and enthusiasm for training young scientists. An equally important criterion is that the laboratory experience will provide research training that can be applied to clinical problems in the major program areas for which the NIADDK is responsible. In Phase II of the program the Physician Scientist will work more independently, though still under the supervision of their basic science sponsor. Although many of the basic research sponsors are MD's or work on problems with immediate clinical relevance, each Physician Scientist will maintain close contact during Phase II with a secondary clinical sponsor who will help the Physician Scientist in the transition from trainee to independent investigator and in the application of basic skills to clinical research. The long-term goal of the program is to provide gifted and dedicated physicians with the opportunity to learn and utilize basic scientific tools as independent investigators working in clinical areas of interest to the NIADDK.

Project Start
1984-07-01
Project End
1989-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wright, T M; Willenberger, S; Raben, D M (1992) Activation of phospholipase D by alpha-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol. Biochem J 285 ( Pt 2):395-400
Wright, T M; Farber, J M (1991) 5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma. J Exp Med 173:417-22
Pratt, R D; Ferreira, G C; Pedersen, P L (1991) Mitochondrial phosphate transport. Import of the H+/Pi symporter and role of the presequence. J Biol Chem 266:1276-80
Leach, K L; Ruff, V A; Wright, T M et al. (1991) Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts. J Biol Chem 266:3215-21
Wright, T M; Shin, H S; Raben, D M (1990) Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis. Biochem J 267:501-7
Raben, D M; Pessin, M S; Rangan, L A et al. (1990) Kinetic and molecular species analyses of mitogen-induced increases in diglycerides: evidence for stimulated hydrolysis of phosphoinositides and phosphatidylcholine. J Cell Biochem 44:117-25
Ferreira, G C; Pratt, R D; Pedersen, P L (1990) Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology. J Biol Chem 265:21202-6
Pratt, R D; Pedersen, P L (1989) Inhibition of Na+-dependent phosphate transport by group-specific covalent reagents in rat kidney brush border membrane vesicles. Evidence for the involvement of tyrosine and sulfhydryl groups on the interior of the membrane. Arch Biochem Biophys 268:9-19
Nishijima, J; Wright, T M; Hoffman, R D et al. (1989) Lysophosphatidylcholine metabolism to 1,2-diacylglycerol in lymphoblasts: involvement of a phosphatidylcholine-hydrolyzing phospholipase C. Biochemistry 28:2902-9
Ferreira, G C; Pratt, R D; Pedersen, P L (1989) Energy-linked anion transport. Cloning, sequencing, and characterization of a full length cDNA encoding the rat liver mitochondrial proton/phosphate symporter. J Biol Chem 264:15628-33

Showing the most recent 10 out of 14 publications