Although knowledge of cancer biology in the laboratory has increased exponentially in recent years, progress in cancer treatment in the clinic has been more gradual. To accelerate progress in the clinic, a larger number of outstanding clinician-investigators is needed to perform patient-oriented, therapeutic translational research. The M.D. Anderson (MDACC) K12 Paul Calabresi Program in Clinical Oncology has taken advantage of an extraordinary environment for clinical and translational research to begin to fill this need. MDACC brings together 1162 faculty and 24,000 new patients each year with a well-developed infrastructure for clinical and laboratory research and novel ideas that are supported by more than 200 NCI grants. For 6 decades, MDACC investigators have made important contributions to clinical cancer research. Since the inception of the MDACC K12 Program in 2000, 5 junior-faculty investigators have been trained in patient-based translational research with the program's support, and 3 others will begin training this fall. This renewal will combine the training program for 4 junior faculty supported by K12 CA99094 with a training program for 3 fellows now supported by K12 CA90891. The trainees will participate in a new, cancer-oriented K30 curriculum and an optional, unique M.S./Ph.D. program in Patient-Based Biological Research. To maximize use of MDACC's extensive resources for clinical, translational and basic research, this combined K12 program will include fellows and junior faculty not only from MDACC but also from other outstanding institutions throughout the United States. Eight universities have already expressed interest. This program emphasizes individualized training plans that include didactic classes, clinical trials, laboratory research projects, publication of results, individualized training experiences, and long-range planning. Each Calabresi scholar is guided by a clinical mentor and a translational mentor as well as the program's Advisory Committee, composed of experts in clinical, laboratory, and translational research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12CA088084-09
Application #
7497097
Study Section
Special Emphasis Panel (ZCA1-RTRB-Z (J1))
Program Officer
Lei, Ming
Project Start
2000-09-13
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
9
Fiscal Year
2008
Total Cost
$545,376
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Ikoma, Naruhiko; Das, Prajnan; Hofstetter, Wayne et al. (2018) Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006-2014 using propensity score matching. Gastric Cancer 21:1004-1013
Raghavendra, Akshara; Sinha, Arup K; Valle-Goffin, Janeiro et al. (2018) Determinants of Weight Gain During Adjuvant Endocrine Therapy and Association of Such Weight Gain With Recurrence in Long-term Breast Cancer Survivors. Clin Breast Cancer 18:e7-e13
Keung, Emily Z; Lazar, Alexander J; Torres, Keila E et al. (2018) Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. BMC Cancer 18:913
Livingston, J Andrew; Wang, Wei-Lien; Tsai, Jen-Wei et al. (2018) Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients. Mol Cancer Ther 17:1315-1323
Rosenberg, Abby R; Bradford, Miranda C; McCauley, Elizabeth et al. (2018) Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial. Cancer 124:3909-3917
Sahin, Ismet; Zhang, Yu; McAllister, Florencia (2018) Tumor Spheres Quantification with Smoothed Euclidean Distance Transform. J Mol Imaging Dyn 8:
MD Anderson Head and Neck Cancer Symptom Working Group; Kamal, Mona; Rosenthal, David I et al. (2018) Patient reported dry mouth: Instrument comparison and model performance for correlation with quality of life in head and neck cancer survivors. Radiother Oncol 126:75-80
Bannon, Sarah A; Montiel, Maria F; Goldstein, Jennifer B et al. (2018) High Prevalence of Hereditary Cancer Syndromes and Outcomes in Adults with Early-Onset Pancreatic Cancer. Cancer Prev Res (Phila) 11:679-686
Joint Head and Neck Radiotherapy-MRI Development Cooperative (2018) Dynamic contrast-enhanced magnetic resonance imaging for head and neck cancers. Sci Data 5:180008
Zhang, Hua; Sturgis, Erich; Zhu, Lijun et al. (2018) The Modifying Effect of a Functional Variant at the miRNA Binding Site in E2F1 Gene on Recurrence of Oropharyngeal Cancer Patients with Definitive Radiotherapy. Transl Oncol 11:633-638

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