The overall goal of this program is to train a group of highly gifted individuals who apply the tools of fundamental science to study the pathophysiology, treatment, and diagnosis of clinical disorders. The Director will work with a Selection and Oversite Committee to choose candidates from a pool of talented houseofficers who have completed at least two years of housestaff training. Selection will be based not only on an individual's qualifications and interests,k but also on their potential, and commitment to bringing fundamental science to clinical problems. The training will be divided into two phases. During phase I (two to three years), the trainee will enroll in formal courses and will begin basic laboratory work in a basic science area under the direction of a basic scientist who has experience in and enthusiasm for training physician scientists. The curriculum will consist of a core of four courses to be taken by all trainees, as well as others to be selected by a mutual decision between the trainee, the preceptor, and the Selection and Oversite Committee. Progress during phase I will be monitored by the preceptor, as well as the Selection Oversite Committee. At the end of two or three years when the trainee, preceptor, and Selection and Oversite Committee feel the individual is ready to move to phase II, the individual will move to a situation in which they bring the fundamental science to address significant questions related to clinical disorders of specific interest of the NIADDK. The supervisor directly responsible for the individual may be the same or different than the supervisor for phase I. Progress during phase Ii will also be monitored by the trainee's supervisor and the Oversite Committee. At the end of five years of training, the individual should be ready to begin a career as an independent investigator working in specific areas of interest to the NIADDK.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK001298-10
Application #
2133519
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1990-07-01
Project End
1998-06-30
Budget Start
1994-07-01
Budget End
1998-06-30
Support Year
10
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Koniaris, L G; Wand, G; Wright, T M (2001) TNF mediates a murine model of Addison's crisis. Shock 15:29-34
Chin, B Y; Petrache, I; Choi, A M et al. (1999) Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. J Biol Chem 274:11362-8
Choi, M E (1999) Cloning and characterization of a naturally occurring soluble form of TGF-beta type I receptor. Am J Physiol 276:F88-95
Mancini, M; Nicholson, D W; Roy, S et al. (1998) The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol 140:1485-95
Choi, M E; Liu, A; Ballermann, B J (1997) Differential expression of transforming growth factor-beta receptors in rat kidney development. Am J Physiol 273:F386-95
Chen, H; Biel, M A; Borges, M W et al. (1997) Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ 8:677-86
Miskovsky, E P; Carrella, A V; Gutekunst, K et al. (1996) Clinical characterization of a competitive PCR assay for quantitative testing of hepatitis C virus. J Clin Microbiol 34:1975-9
Choi, M E; Ballermann, B J (1995) Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors. J Biol Chem 270:21144-50
Nelkin, B D; Ball, D W; Baylin, S B (1994) Molecular abnormalities in tumors associated with multiple endocrine neoplasia type 2. Endocrinol Metab Clin North Am 23:187-213
Willoughby, R E (1993) Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins. Glycobiology 3:437-45

Showing the most recent 10 out of 26 publications