The University of California at San Diego (UCSD) and San Diego State University (SDSU) propose to continue a successful institutional research and academic career development award (IRACDA) program for postdoctoral scholars. Six trainees will enter each year for a 3-year training period. The San Diego IRACDA Program will recruit and train under-represented postdoctoral fellows in top research labs, coupling mentored research with focused training in teaching, research ethics, grant writing, lab management, and a variety of professorial skills. The immediate goals are to help these postdocs begin independent research careers with appropriate skills to succeed, and to place IRACDA Fellows in tenure track jobs within the UC and California State University systems. The long-term goal is to increase the number of under-represented faculty and faculty committed to the education of URMs nation-wide. Research training will occur primarily at UCSD, and will include weekly lab meetings, departmental seminars, evaluated research presentations, monthly meetings with the PI, a course in research ethics, courses in grant and paper writing, and annual attendance at a national meeting (poster presentations in years 2 and 3) and the National IRACDA meeting. These activities will be coordinated by Drs. Brunton and Villarreal. Teaching will occur at SDSU, under the coordination of Dr. Pozos, in a design that keeps the emphasis on continual research progress. Following a six month period in the lab to establish their research, fellows will prepare &deliver 3 lectures per semester in a beginning biology course for 5 semesters, with training in classroom management, advising, assessment, e-curriculum development, and development of individual teaching styles. The academic emphasis is on mammalian systems biology, which also expands the Fellows' knowledge, since many of them have specialized without comprehensive training in biology. Expectations are substantial esprit de corps amongst Fellows, a major publication during year two, a research grant in draft form by the second half of year three, a portfolio of exemplary lectures by the end of year three, and a more advanced position or job offer at the end of year three. Fellows will be followed for ten years from the start of the program (roughly to the time of a tenure decision) and their progress compared to that of the general pool of postdoctoral fellows on the two campuses, majority postdocs in the San Diego IRACDA, other postdoctoral fellows in the same labs, and, as data become available, the national pool of NIH-supported postdocs.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Physician Scientist Award (Program) (PSA) (K12)
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Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Poodry, Clifton A
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University of California San Diego
Schools of Medicine
La Jolla
United States
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Jensen, S B; Hindberg, K; Solomon, T et al. (2018) Discovery of novel plasma biomarkers for future incident venous thromboembolism by untargeted synchronous precursor selection mass spectrometry proteomics. J Thromb Haemost 16:1763-1774
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Ita, Sergio; Hill, Alison K; Lam, Evan C et al. (2018) High-Resolution Sequencing of Viral Populations during Early Simian Immunodeficiency Virus Infection Reveals Evolutionary Strategies for Rapid Escape from Emerging Env-Specific Antibody Responses. J Virol 92:
Tinoco, Roberto; Carrette, Florent; Henriquez, Monique L et al. (2018) Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol 200:2690-2702
Wang, Huawei; Lapek, John; Fujimura, Ken et al. (2018) Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov 4:26
Solomon, Terry; Lapek Jr, John D; Jensen, Søren Beck et al. (2018) Identification of Common and Rare Genetic Variation Associated With Plasma Protein Levels Using Whole-Exome Sequencing and Mass Spectrometry. Circ Genom Precis Med 11:e002170
Claw, Katrina G; Anderson, Matthew Z; Begay, Rene L et al. (2018) A framework for enhancing ethical genomic research with Indigenous communities. Nat Commun 9:2957
Jiang, Qingfei; Jamieson, Catriona (2018) BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell 33:3-5
Hernandez-Carretero, A; Weber, N; La Frano, M R et al. (2018) Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond) 42:728-736
Hernandez-Carretero, Angelina; Weber, Natalie; LaBarge, Samuel A et al. (2018) Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab 315:E267-E278

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