This is a competitive renewal application for continued support under new leadership, for the Reproductive Scientist Development Program (RSDP), a multi-disciplinary, multi-institutional research career development program for obstetrician-gynecologists in cell and molecular biology and related fundamental sciences. The objective of this program is to educate obstetrician-gynecologists in contemporary basic science research related to reproductive medicine and biology in order to prepare them for research careers in academic medicine. The overall goal is to help ensure that academic obstetrics and gynecology fulfills its mission to increase research and discovery in the reproductive sciences. Outstanding MD/PhD, PhD, and MD scientists with broad research experience serve as faculty mentors. A unique feature of this program is that outstanding individuals, upon completing a residency in obstetrics and gynecology, and in many cases two or three years of clinical subspecialty fellowship, spend two to three years (Phase I) in fundamental science research laboratories under the supervision and mentorship of experienced, highly regarded accomplished scientists. During Phase I, Scholars are dedicated to full-time research with no clinical obligations. Following this experience, Scholars spend an additional three-year period establishing their research program in a Department of Obstetrics and Gynecology (Phase II). Here, the Scholar serves as a junior faculty member with at least 75% time devoted to developing an independent research career. Historically, Phase I has been entirely funded by NICHD and Phase II has been funded from a number of possible sources, including NIH an private grants, and from contributions to the RSDP program from the obstetrics and gynecologic societies, from philanthropic foundation, industry, departmental, and other sources. This funding mechanism will continue, however, NIH funding will support up to 3 Scholars for the duration of Phase I and Phase II. Upon completion of this program, the Scholar is expected to continue to pursue a career as a productive physician-scientist investigator. This program serves as a model to education increased numbers of reproductive scientists to develop into leaders in academic Departments of Obstetrics and Gynecology, and this is now occurring.

Public Health Relevance

The Reproductive Scientist Development Program plan for career development serves as a model for postgraduate medical education, and assures that some of the most promising young physician-investigators in the country will remain in academic investigative obstetrics and gynecology. A great majority of the Scholars who have finished Phase II of the Program have dedicated themselves to research in the reproductive sciences and have developed major independent funding support. To date their productivity has been outstanding, has contributed greatly to the reproductive sciences, and is a credit for the Program.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHD1)
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Lamar, Charisee A
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Washington University
Obstetrics & Gynecology
Schools of Medicine
Saint Louis
United States
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Yu, Bo; Vega, Mario; Zaghi, Sahar et al. (2018) Comparison of perinatal outcomes following frozen embryo transfer cycles using autologous versus donor oocytes in women 40 to 43 years old: analysis of SART CORS data. J Assist Reprod Genet 35:2025-2029
Roberts, Victoria H J; Lo, Jamie O; Lewandowski, Katherine S et al. (2018) Adverse Placental Perfusion and Pregnancy Outcomes in a New Nonhuman Primate Model of Gestational Protein Restriction. Reprod Sci 25:110-119
Lo, Jamie O; Roberts, Victoria H J; Schabel, Matthias C et al. (2018) Novel Detection of Placental Insufficiency by Magnetic Resonance Imaging in the Nonhuman Primate. Reprod Sci 25:64-73
Quinn, Jeanne M; Greenwade, Molly M; Palisoul, Marguerite L et al. (2018) Therapeutic Inhibition of the Receptor Tyrosine Kinase AXL Improves Sensitivity to Platinum and Taxane in Ovarian Cancer. Mol Cancer Ther :
Van Arsdale, Anne R; Arend, Rebecca C; Cossio, Maria J et al. (2018) Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med 7:616-625
Grither, Whitney R; Divine, Laura M; Meller, Eric H et al. (2018) TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. Oncogene 37:1714-1729
Edlow, Andrea G; Glass, Ruthy M; Smith, Caroline J et al. (2018) Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity. Int J Dev Neurosci :
Kallen, Amanda; Polotsky, Alex J; Johnson, Joshua (2018) Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends Mol Med 24:319-331
Reed, Beverly G; Babayev, Samir N; Chen, Lucy X et al. (2018) Estrogen-regulated miRNA-27b is altered by bisphenol A in endometrial stromal cells Reproduction :
Brayboy, Lynae M; Clark, Haley; Knapik, Laura O et al. (2018) Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes. Reprod Toxicol 82:80-87

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