This renewal application seeks NICHD support for 5 first-year and 5 second-year positions in the Pediatric Scientist Development Program (PSDP), a career development pathway for pediatric fellows from which 192 physician-scientists have graduated since 1987. The objectives of the program remain unchanged since its inception: (a) to recruit pediatric fellows whose outstanding potential for a successful investigative career can be developed in an intensively mentored setting and (b) to expand the pipeline of superbly trained pediatric physician-scientists, who will catalyze cutting-edge discoveries in child health and lead the pediatric departments of the future. Unique aspects of the PSDP include its North American scope for recruitment of fellows and mentors, its intensive focus on career development during fellowship, its supra-institutional governance under the aegis of the Association of Medical School Pediatric Department Chairs (AMSPDC), its emphasis on research environments outside departments of pediatrics, and its approach to mentoring that encompasses research mentors, PSDP advisory committees, and pediatric department chairs. Advisory Committees include a Steering Committee, which sets programmatic policy; a Selection Committee to interview PSDP candidates; and an independent Program Evaluation Committee measures the program?s effectiveness in ensuring fellows? success. A centerpiece of the PSDP is the annual career development curriculum that convenes PSDP fellows, advisory committees, and all US and Canadian pediatric department chairs at the AMSPDC meeting. PSDP graduates have served as PIs on 335 NIH RPGs, of which 53% are currently active. Based on total awards of NIH RPGs with PSDP graduates are PIs, the return on NICHD investment is 8.8 fold. Innovations for 2017-2021 include a) leveraging NICHD funding by incorporating departmental support for up to 5 third-year fellows who will be appointed as instructors with 75-80% protected research time and b) expanding our career development curriculum with adult-learning educational modules that emphasize the fellow-to-faculty transition and team science, presented on site at AMSPDC and through web-based case-based studies. The PSDP has implemented a comprehensive strategy to expand the boundaries of child health research, to develop the research careers of rigorously trained pediatric physician-scientists, and to produce the next generation of investigative leaders in pediatrics.

Public Health Relevance

As the percentage of children in the US population surpasses 20%, pediatric diseases such as prematurity, infections, asthma, obesity, and childhood heart disease and cancer claim an ever-greater share of the public health burden. The recognition that many adult diseases such as diabetes or mental illness have roots in childhood also creates a pressing need for investigation. The Pediatric Scientist Development Program provides pediatricians with the scientific training to discover the causes and cures of childhood illness.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12HD000850-33
Application #
9402296
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Winer, Karen
Project Start
1986-12-01
Project End
2022-06-30
Budget Start
2017-07-06
Budget End
2018-06-30
Support Year
33
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Choudhary, Rewa K; Wall, Kristin M; Njuguna, Irene et al. (2018) Monocyte-to-lymphocyte ratio is associated with tuberculosis disease and declines with anti-TB treatment in HIV-infected children. J Acquir Immune Defic Syndr :
Balkin, Emily Morell; Zinter, Matt S; Rajagopal, Satish K et al. (2018) Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension. Pediatr Crit Care Med 19:733-740
Nagata, Jason M; Hathi, Sejal; Ferguson, B Jane et al. (2018) Research priorities for adolescent health in low- and middle-income countries: A mixed-methods synthesis of two separate exercises. J Glob Health 8:010501
Nagata, Jason M; Ferguson, B Jane; Ross, David A (2018) Minding the Gap: Setting Research Priorities Related to HIV Testing, Treatment, and Service Delivery Among Adolescents. J Adolesc Health 63:131-132
Duarte, Horacio A; Beck, Ingrid A; Levine, Molly et al. (2018) Implementation of a point mutation assay for HIV drug resistance testing in Kenya. AIDS 32:2301-2308
Lake, Blue B; Chen, Song; Sos, Brandon C et al. (2018) Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat Biotechnol 36:70-80
Nagata, Jason M; Carlson, Jennifer L; Golden, Neville H et al. (2018) Associations between exercise, bone mineral density, and body composition in adolescents with anorexia nervosa. Eat Weight Disord :
Nagata, Jason M; Garber, Andrea K; Buckelew, Sara M (2018) Weight restoration in atypical anorexia nervosa: A clinical conundrum. Int J Eat Disord 51:1290-1293
Lee, Nathanael J; Ha, Seung-Kwon; Sati, Pascal et al. (2018) Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain 141:1637-1649
Hooven, Thomas A; Catomeris, Andrew J; Bonakdar, Maryam et al. (2018) The Streptococcus agalactiae Stringent Response Enhances Virulence and Persistence in Human Blood. Infect Immun 86:

Showing the most recent 10 out of 350 publications