The long-term objective of the proposed training is to develop a new generation of physician-scientists at Wayne State University who will sustain independent careers in basic, translational, and/or clinical research related to women's reproductive health. The immediate objective is to provide highly individualized research training to the four OB/GYN-qualified physicians who will be our first Women's Reproductive Health Research Scholars. They will be selected by the Advisory Committee from local and national candidate pools. The most important selection criteria to be used will be dedication to research, because to attain our long-term objective, the graduates of this program must retain career-long commitments to independent scholarly investigation. Each will be guaranteed at least 75 percent FTE effort for research that they plan, direct and execute. There will be five training aims: 1) Provide coursework that will complete the preparation of each Scholar for a career in independent research; 2) Provide each Scholar with a critical mentored research experience relevant to his/her long-term research interests; 3) Assure that each Scholar is well-grounded in the responsible conduct of research; 4) Assure that each Scholar can write a competitive grant application; and 5) Proactively network each Scholar with senior, established investigators who are prominent in his/her field of research. Mentors will be chosen by Scholars from a pool of highly qualified researchers. Scholars will graduate from the program when they have reached research independence, as judged by publications, ability to acquire independent extramural peer-reviewed research support, and eligibility for independent research space and start-up funds. Replacement Scholars will then be recruited, allowing up to eight physician-scientists to be trained during the funding period. Many different indicators underscore that commitment to the development and retention of Scholars as research-oriented faculty members is high, both at the institutional and departmental levels. The past and current research environment in which Scholars will be trained is exceptional, including (during the past five years) center grants in six separate departmental divisions; over 100 refereed publications/year by departmental faculty; and extramural research support that has averaged $6.5 million/year. In addition, a 50,000 ft2 state of the art building, which is assigned exclusively to the Obstetrics and Gynecology Department, is dedicated to women's reproductive health research.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001254-02
Application #
6125441
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (04))
Program Officer
Parrott, Estella C
Project Start
1998-12-01
Project End
2003-11-30
Budget Start
1999-12-01
Budget End
2000-11-30
Support Year
2
Fiscal Year
2000
Total Cost
$400,000
Indirect Cost
Name
Wayne State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Recanati, Maurice A; Kramer, Katherine J; Maggio, John J et al. (2018) Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial. Clin Exp Obstet Gynecol 45:383-386
Shaeib, Faten; Khan, Sana N; Ali, Iyad et al. (2016) The Defensive Role of Cumulus Cells Against Reactive Oxygen Species Insult in Metaphase II Mouse Oocytes. Reprod Sci 23:498-507
Jain, Chandni V; Kadam, Leena; van Dijk, Marie et al. (2016) Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal. Sci Transl Med 8:363re4
Yang, Yu; Xu, Yanwen; Ding, Chenhui et al. (2016) Comparison of 2, 5, and 20 % O2 on the development of post-thaw human embryos. J Assist Reprod Genet 33:919-27
Mehta, Shobha H; Kruger, Michael; Sokol, Robert J (2015) Institute of Medicine Guidelines for Appropiate Pregnancy Weight Gain for Obese Women May Be Too High. J Reprod Med 60:324-8
Fritz, Rani; Kohan-Ghadr, Hamid-Reza; Bolnick, Jay M et al. (2015) Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC). Fertil Steril 104:339-46.e4
Belotte, Jimmy; Fletcher, Nicole M; Alexis, Mitchell et al. (2015) Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancer. Reprod Sci 22:38-46
Fritz, Rani; Kohan-Ghadr, Hamid Reza; Sacher, Alex et al. (2015) Trophoblast retrieval and isolation from the cervix (TRIC) is unaffected by early gestational age or maternal obesity. Prenat Diagn 35:1218-22
Armant, D R; Fritz, R; Kilburn, B A et al. (2015) Reduced expression of the epidermal growth factor signaling system in preeclampsia. Placenta 36:270-8
Belotte, Jimmy; Fletcher, Nicole M; Saed, Mohammed G et al. (2015) A Single Nucleotide Polymorphism in Catalase Is Strongly Associated with Ovarian Cancer Survival. PLoS One 10:e0135739

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