The University of Iowa Child Health Research Career Development Award (CHRCDA) entitled ?Molecular and Cellular Research to Advance Child Health? was originally established in 1990 when NICHD first developed the program. Since inception, our CHRCDA program has facilitated the career development of 39 junior pediatric faculty. Our program is designed to support the academic career development of promising junior pediatric faculty. Given our history, we anticipate training 8-12 Scholars for the 5-year duration of this award. This program takes advantage of our present strenths, existing research programs, and established investigators by placing particular emphasis on four major areas of pediatric research, namely Molecular Genetics, Cardiovascular Biology, Neurosciences and Host Defenses. Specifically, this program will support and foster research training of junior pediatric physician-scientists in cellular and molecular biology, applied genetics and genomics, animal models of human disease, and translational research. The specific long-term goals and objectives of this program are: (1) to provide junior pediatric physician scientists with the research background and approaches to problem solving that they can apply to current and future studies of the genetics and functional basis of diseases that impact broadly on children's health; (2) to give junior pediatric physician-scientists formal instruction in a curriculum considered relevant and necessary for the pursuit of a successful academic research career; (3) to provide a unique environment for junior pediatric physician- scientists to study gene funciton across the biological spectrum from regulation at the molecular level thorough to whole organism physiology; (4) to provide junior pediatric physician-scientists with an opportunity to acquire new, innovative and state-of-the-art scientific research expertise in molecular and cellular biology, physiologic genomics, neuroscience and translational research to bridge the gap between basic science research and clinical pediatric medicine; (5) to attract the most talented junior pediatric physician-scientists and to recruit, develop and train minority and women as independent investigators. To achieve these aims we have recruited 41 senior faculty Mentors from diverse departments and units throughout the Department of Pediatrics, the Howard Hughes Medical Institute, and the College of Medicine. Oversight of the program will be achieved through regularly scheduled meetings of an Internal Advisory Committee and presentations by each of the Scholars. In addition, an External Advisory Committee will meet onsite annually to review the program, assess progress of the Scholars, and provide feedback regarding the effectiveness and operations of the program. This program will ultimately improve the health and well being of children through innovative research fostered by the development of newly trained and highly effective child health research clinician-scientists.

Public Health Relevance

The University of Iowa Child Health Research Career Development Award will ultimately improve the health and well-being of children through innovative research fostered by development of newly trained and highly effective clinician scientists.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD027748-28
Application #
9824548
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Bremer, Andrew
Project Start
2002-02-20
Project End
2022-11-30
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
28
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Iowa
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Boes, Aaron D; Fischer, David; Geerling, Joel C et al. (2018) Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness. Sleep 41:
Boes, Aaron D; Uitermarkt, Brandt D; Albazron, Fatimah M et al. (2018) Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression. Brain Stimul 11:575-581
Meyer, Lauritz R; Dexter, Benjamin; Lo, Cecilia et al. (2018) Perinatal SSRI exposure permanently alters cerebral serotonin receptor mRNA in mice but does not impact adult behaviors. J Matern Fetal Neonatal Med 31:1393-1401
Zepeda-Orozco, Diana; Wen, Hsiang M; Hamilton, Bradley A et al. (2017) EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep 5:
Kaye, Harper L; Gersner, Roman; Boes, Aaron D et al. (2017) Persistent uncrossed corticospinal connections in patients with intractable focal epilepsy. Epilepsy Behav 75:66-71
Kelly, Michael S; Oliveira-Maia, Albino J; Bernstein, Margo et al. (2017) Initial Response to Transcranial Magnetic Stimulation Treatment for Depression Predicts Subsequent Response. J Neuropsychiatry Clin Neurosci 29:179-182
Haskell, Sarah E; Lo, Cecilia; Kent, Mitchell E et al. (2017) Cardiac Outcomes After Perinatal Sertraline Exposure in Mice. J Cardiovasc Pharmacol 70:119-127
Brumbaugh, Jane E; Conrad, Amy L; Lee, Jessica K et al. (2016) Altered brain function, structure, and developmental trajectory in children born late preterm. Pediatr Res 80:197-203
Manoli, Irini; Myles, Jennifer G; Sloan, Jennifer L et al. (2016) A critical reappraisal of dietary practices in methylmalonic acidemia raises concerns about the safety of medical foods. Part 1: isolated methylmalonic acidemias. Genet Med 18:386-95
Schofield, Thomas J; Conger, Rand D; Gonzales, Joseph E et al. (2016) Harsh parenting, physical health, and the protective role of positive parent-adolescent relationships. Soc Sci Med 157:18-26

Showing the most recent 10 out of 25 publications