This is a renewal application, and would provide funding to administer the Neurosurgeon Research Career Development Program (NRCDP) for another five years. The purpose of this award is to provide the basis for a continued national effort to support, train, and mentor junior neurosurgical faculty members at appropriate institutions nationwide. This application describes all key aspects for the mechanism of recruiting applicants and the developing them into surgeon-scientists through continuing the NRCDP. The proposal addresses topics such as the rationale for the program, the relevant history of the PI and Institution, and the ongoing need for the NRCDP. The proposal also addresses the rationale for the selection of a National Advisory Committee (NAC). It also details a well-developed system for the recruitment of applicants. In addition, there is a description of the existing and robust system for selection of scholar-applicants based on their potential for success, the track record of their mentor, and the support of their Chairpersons. In addition, there are details of an annual three-day retreat, which has been held for five years, that includes applicant interviews, lectures, and interactive grant writing sessions. Finally, there is a description of the advisory board meeting for review of applications. This program has been extremely successful. Five years ago, when this NRCDP was first awarded, a search of NINDS data revealed only 4 neurosurgeons with active K08 awards. Currently, there are a total of 12 neurosurgeons with active K08 awards. Of the currently active K08 awards, four are scholars of this NRCDP program and two were applicants. In other words, over the five-year span of the NRCDP, there has been roughly a 300% increase in neurosurgeon K08 awards. Moreover, 50% of all current NINDS K08?s, awarded to neurosurgeons, are affiliated with the NRCDP either through direct support or through participation in the program. Another three alumni obtained independent federal funding through other mechanisms. If the scholars funded in 2016 are excluded from the analysis, which is reasonable given that they have only been funded for a few months, then 7 out of 10, or 70%, of scholars have successfully obtained independent federal funding in a relatively short period of time. In our opinion, this is an excellent success rate. Perhaps as importantly, the NRCDP has fostered a healthy and burgeoning community of junior neurosurgeon-scientists that will form the basis for reinvigoration the long tradition of scientific research in neurosurgery.

Public Health Relevance

The goal of this proposal is to describe an existing and robust system for identifying, selecting, and supporting promising neurosurgeons in the early stage of their career, when they are most vulnerable, so that they can successfully mature into independent and productive neurosurgeon scientists that will lead the way for developing new and better treatments for a wide range of neurological disorders. The first five years of the program were quite successful. We fully expect continued enhancements and greater success in the next five years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
6K12NS080223-07
Application #
9855191
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2012-07-01
Project End
2023-06-30
Budget Start
2019-01-01
Budget End
2019-06-30
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
081266487
City
Bronx
State
NY
Country
United States
Zip Code
10461
Connolly, Nina P; Shetty, Amol C; Stokum, Jesse A et al. (2018) Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. Sci Rep 8:1180
Wu, Hemmings; Miller, Kai J; Blumenfeld, Zack et al. (2018) Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man. Proc Natl Acad Sci U S A 115:192-197
Nanda, Pranav; Banks, Garrett P; Pathak, Yagna J et al. (2017) Connectivity-based parcellation of the anterior limb of the internal capsule. Hum Brain Mapp 38:6107-6117
Sklar, Samuel; Walmer, Matthew; Sacre, Pierre et al. (2017) Neuronal activity in human anterior cingulate cortex modulates with internal cognitive state during multi-source interference task. Conf Proc IEEE Eng Med Biol Soc 2017:962-965
Bentley, R Timothy; Ahmed, Atique U; Yanke, Amy B et al. (2017) Dogs are man's best friend: in sickness and in health. Neuro Oncol 19:312-322
Nimjee, Shahid M; White, Rebekah R; Becker, Richard C et al. (2017) Aptamers as Therapeutics. Annu Rev Pharmacol Toxicol 57:61-79
Lee, Karen E; Bhati, Mahendra T; Halpern, Casey H (2016) A Commentary on Attitudes Towards Deep Brain Stimulation for Addiction. J Neurol Neuromedicine 1:1-3
Dey, Mahua; Yu, Dou; Kanojia, Deepak et al. (2016) Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma. Stem Cell Reports 7:471-482
Hersh, David S; Nguyen, Ben A; Dancy, Jimena G et al. (2016) Pulsed ultrasound expands the extracellular and perivascular spaces of the brain. Brain Res 1646:543-550
Hersh, David S; Kim, Anthony J; Winkles, Jeffrey A et al. (2016) Emerging Applications of Therapeutic Ultrasound in Neuro-oncology: Moving Beyond Tumor Ablation. Neurosurgery 79:643-654

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