Abstract

Dr. Lyles' thesis proposal concerns the interactions of purines and polynuclear aromatic hydrocarbons through polarization bonding. The research will attempt to prove that this interaction can significantly reduce the carcinogenic potential of these compounds. The results could lead to new concepts in the treatment of cancers resulting from these environmental hazards.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
2K16DE000152-11
Application #
5210008
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Lyles, Mark B; Cameron, Ivan L (2002) Caffeine and other xanthines as cytochemical blockers and removers of heterocyclic DNA intercalators from chromatin. Cell Biol Int 26:145-54
Lyles, Mark B; Cameron, Ivan L (2002) Interactions of the DNA intercalator acridine orange, with itself, with caffeine, and with double stranded DNA. Biophys Chem 96:53-76
Lyles, M B; Cameron, I L; Rawls, H R (2001) Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. J Med Chem 44:4650-60
Flynn, M A; Qiao, M; Garcia, C et al. (1999) Avian osteoclast cells are stimulated to resorb calcified matrices by and possess receptors for leukotriene B4. Calcif Tissue Int 64:154-9
Dongari-Bagtzoglou, A I; Ebersole, J L (1998) Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis. J Periodontol 69:899-910
Novak, K F; Lee, L N; LeBlanc, D J (1998) Functional analysis of pVT745, a plasmid from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 13:124-8
Dongari-Bagtzoglou, A I; Warren, W D; Berton, M T et al. (1997) CD40 expression by gingival fibroblasts: correlation of phenotype with function. Int Immunol 9:1233-41
Klebe, R J; Grant, G M; Grant, A M et al. (1996) RT-PCR without RNA isolation. Biotechniques 21:1094-100
Hill, S J; Ebersole, J L (1996) The effect of lipopolysaccharide on growth factor-induced mitogenesis in human gingival fibroblasts. J Periodontol 67:1274-80
Dongari-Bagtzoglou, A I; Ebersole, J L (1996) Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 67:871-8

Showing the most recent 10 out of 34 publications