As of July 1996, I have completed two years of my OMS residency training. This includes all required off service rotations such as medicine, surgery and anesthesia. I will complete my residency training in June of 1998. I have also completed my written and oral qualifying exams for PhD candidacy and have approval of my dissertation proposal. I expect to defend my dissertation in the spring of 1997. Over the last two years I have been co-author on six publications and an abstract. I have also given lectures to undergraduate dental students on a variety of subjects including neoplasms, psychological disorders and dental-legal risk management. I presented an abstract in the 1994 AADR in San Antonio entitled """""""" Regulation of Collagenase Gene Expression"""""""". In the fall of '96 I will participate in a surgical campaign to Cordoba Mexico as part of an international team for the treatment of cleft lips and palates. This is a wonderful opportunity for a learning experience and a chance to help people who would otherwise not have access to this type of medical care. I also will be completing another manuscript for publication concerned with the promoter response elements involved in the regulation of matrix metalloproteinases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
2K16DE000152-11
Application #
5210009
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Lyles, Mark B; Cameron, Ivan L (2002) Caffeine and other xanthines as cytochemical blockers and removers of heterocyclic DNA intercalators from chromatin. Cell Biol Int 26:145-54
Lyles, Mark B; Cameron, Ivan L (2002) Interactions of the DNA intercalator acridine orange, with itself, with caffeine, and with double stranded DNA. Biophys Chem 96:53-76
Lyles, M B; Cameron, I L; Rawls, H R (2001) Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. J Med Chem 44:4650-60
Flynn, M A; Qiao, M; Garcia, C et al. (1999) Avian osteoclast cells are stimulated to resorb calcified matrices by and possess receptors for leukotriene B4. Calcif Tissue Int 64:154-9
Dongari-Bagtzoglou, A I; Ebersole, J L (1998) Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis. J Periodontol 69:899-910
Novak, K F; Lee, L N; LeBlanc, D J (1998) Functional analysis of pVT745, a plasmid from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 13:124-8
Dongari-Bagtzoglou, A I; Warren, W D; Berton, M T et al. (1997) CD40 expression by gingival fibroblasts: correlation of phenotype with function. Int Immunol 9:1233-41
Klebe, R J; Grant, G M; Grant, A M et al. (1996) RT-PCR without RNA isolation. Biotechniques 21:1094-100
Hill, S J; Ebersole, J L (1996) The effect of lipopolysaccharide on growth factor-induced mitogenesis in human gingival fibroblasts. J Periodontol 67:1274-80
Dongari-Bagtzoglou, A I; Ebersole, J L (1996) Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 67:871-8

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