Abstract

My research involves a biochemical approach to defining the isoforms of the CD43 molecule. Using a chemiluminescent detection system, western blots of whole cell lysates has revealed the S11 mAb recognizes four species of molecules. In contrast, the S7 MAb detects only one. The further characterization of these species is the next step in my research which will include metabolic labeling and pulse chase experiments. We have begun collaboration with Blair Audman at Tufts University to develop a CD43 """"""""knockout"""""""" mouse. A manuscript describing my findings with the CD43 molecule has been submitted.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
2K16DE000175-12
Application #
6238327
Study Section
Project Start
1997-07-01
Project End
1998-06-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
12
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Perinpanayagam, H; Schneider, G; Holtman, K et al. (2004) Altered Cbfa1 expression and biomineralization in an osteosarcoma cell line. J Orthop Res 22:404-10
Armstrong, Steven R; Vargas, M A; Chung, I et al. (2004) Resin-dentin interfacial ultrastructure and microtensile dentin bond strength after five-year water storage. Oper Dent 29:705-12
Timmons, Sherry R; Nwankwo, Joseph O; Domann, Frederick E (2002) Acetaldehyde activates Jun/AP-1 expression and DNA binding activity in human oral keratinocytes. Oral Oncol 38:281-90
Armstrong, S R; Keller, J C; Boyer, D B (2001) The influence of water storage and C-factor on the dentin-resin composite microtensile bond strength and debond pathway utilizing a filled and unfilled adhesive resin. Dent Mater 17:268-76
Armstrong, S R; Keller, J C; Boyer, D B (2001) Mode of failure in the dentin-adhesive resin-resin composite bonded joint as determined by strength-based (muTBS) and fracture-based (CNSB) mechanical testing. Dent Mater 17:201-10
Armstrong, S R; Boyer, D B; Keller, J C (1998) Microtensile bond strength testing and failure analysis of two dentin adhesives. Dent Mater 14:44-50
Kurago, Z B; Lutz, C T; Smith, K D et al. (1998) NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells. J Immunol 160:1573-80
Armstrong, S R; Boyer, D B; Keller, J C et al. (1998) Effect of hybrid layer on fracture toughness of adhesively bonded dentin-resin composite joint. Dent Mater 14:91-8
Baumgardner, K R; Walton, R E; Osborne, J W et al. (1996) Induced hypoxia in rat pulp and periapex demonstrated by 3H-misonidazole retention. J Dent Res 75:1753-60
Kurago, Z B; Smith, K D; Lutz, C T (1995) NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells. J Immunol 154:2631-41

Showing the most recent 10 out of 12 publications