Abstract

Il-lB is a key molecule in immunologic as well as inflammatory processes and is thought to be the major mediator stimulating bone loss in periodontal and arthritic diseases. The receptor proteins for Il-lB have been cloned and named Il-1 type I and type II receptors (Il-lRI, Il-lRlI) and Il-l receptor accessory protein (Il-lRAcP). The goal of these studies is to better understand the signal transduction mechanisms of Il-lB. To this end, various mutant cDNA constructs are being developed for eukaryotic transient transfection assays. Different dominant negative and positive expression systems will be tested to dissect out complex protein-protein interactions and activation of known gene transcription factors. It is hoped that understanding signal transduction of Il-lB may lead to improved therapeutic approaches to degenerative inflammatory diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
5K16DE000275-08
Application #
6270239
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

McDermott, Nancy E; Chuang, Sung-Kiang; Woo, Valerie V et al. (2006) Maxillary sinus augmentation as a risk factor for implant failure. Int J Oral Maxillofac Implants 21:366-74
Chuang, S K; Cai, T; Douglass, C W et al. (2005) Frailty approach for the analysis of clustered failure time observations in dental research. J Dent Res 84:54-8
Chuang, S-K; Hatch, J P; Rugh, J et al. (2005) Multi-center randomized clinical trials in oral and maxillofacial surgery: modeling of fixed and random effects. Int J Oral Maxillofac Surg 34:341-4
Treister, Nathaniel S; Woo, Sook-Bin; O'Holleran, Eileen W et al. (2005) Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11:721-31
Woo, Valerie V; Chuang, Sung-Kiang; Daher, Shadi et al. (2004) Dentoalveolar reconstructive procedures as a risk factor for implant failure. J Oral Maxillofac Surg 62:773-80
Halpern, Leslie R; Carter, Jeffrey B; Chuang, Sung-Kiang et al. (2003) A comparison of 2 consultation and treatment strategies to manage impacted third molars. J Oral Maxillofac Surg 61:779-84
Basile, John R; Eichten, Alexandra; Zacny, Valerie et al. (2003) NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes. Mol Cancer Res 1:262-70
McDermott, Nancy E; Chuang, Sung-Kiang; Woo, Valerie V et al. (2003) Complications of dental implants: identification, frequency, and associated risk factors. Int J Oral Maxillofac Implants 18:848-55
Vehemente, Valerie A; Chuang, Sung-Kiang; Daher, Shadi et al. (2002) Risk factors affecting dental implant survival. J Oral Implantol 28:74-81
Chuang, S K; Tian, L; Wei, L J et al. (2002) Predicting dental implant survival by use of the marginal approach of the semi-parametric survival methods for clustered observations. J Dent Res 81:851-5

Showing the most recent 10 out of 32 publications