The overarching goal of this application is to expand patient-oriented research on aging at Yale University School of Medicine--through the proposed research project and development of the Yale Mentorship Program in Patient-Oriented Research on Aging. Patient-oriented research represents the methodologically rigorous process for translating clinical investigation from its theoretical basis to practical intervention strategies to improve clinical care. Thus, this application will foster studies evaluating intervention effectiveness (eg, intervention trials, long-term effectiveness and cost-effectiveness studies) and intervention development studies (eg, studies of prevalence, risk factors, prognosis, and predictive models for clinical conditions).
The specific aims of the proposed research project are to extend the preliminary analyses of the Delirium Intervention Trial--a multicomponent intervention strategy demonstrated to be effective in reducing the incidence of delirium in a clinical trial involving 426 intervention and 426 usual care subjects--to examine secondary outcomes, long-term outcomes, individual intervention components, effects of adherence, and cost-effectiveness. The goals of the Mentorship Program are to provide research mentorship in patient-oriented research on aging to 4-5 candidates per year allowing them to complete a research project. The program will include didactic training, hands-on research mentorship, and a research infrastructure (data analytic and research assistant support). The Yale environment provides the ideal setting, replete with interdisciplinary research and training programs, interdisciplinary expertise and collaboration, and resources (eg, methodological consultation, biostatistical support, access to study populations and databases) to facilitate this program. Sharon K. Inouye, MD, MPH, a respected clinician, widely renowned investigator in patient-oriented research, and experienced mentor, is imminently well-qualified to oversee all aspects of its application. This application, through the proposed research project and the Mentorship Program--with the potential to develop a new cadre of physicians dedicated to patient-oriented research on aging--holds substantial implications for improving health care and quality of life for the older population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Buckholtz, Neil
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Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
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Vasunilashorn, Sarinnapha M; Dillon, Simon T; Inouye, Sharon K et al. (2017) High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery. J Am Geriatr Soc 65:e109-e116
Cavallari, Michele; Hshieh, Tammy T; Guttmann, Charles R G et al. (2015) Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia. Neurobiol Aging 36:2122-9
Kara, Eleanna; Kiely, Aoife P; Proukakis, Christos et al. (2014) A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations. JAMA Neurol 71:1162-71
Fong, Tamara G; Jones, Richard N; Marcantonio, Edward R et al. (2012) Adverse outcomes after hospitalization and delirium in persons with Alzheimer disease. Ann Intern Med 156:848-56, W296
Fong, Tamara G; Inouye, Sharon K; Dai, Weiying et al. (2011) Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction? Brain Imaging Behav 5:25-35
SteelFisher, Gillian K; Martin, Lauren A; Dowal, Sarah L et al. (2011) Sustaining clinical programs during difficult economic times: a case series from the Hospital Elder Life Program. J Am Geriatr Soc 59:1873-82
Rubin, Fred H; Neal, Kelly; Fenlon, Kerry et al. (2011) Sustainability and scalability of the hospital elder life program at a community hospital. J Am Geriatr Soc 59:359-65
Ramaswamy, Ravishankar; Dix, Edward F; Drew, Janet E et al. (2011) Beyond grand rounds: a comprehensive and sequential intervention to improve identification of delirium. Gerontologist 51:122-31
Jones, Richard N; Fong, Tamara G; Metzger, Eran et al. (2010) Aging, brain disease, and reserve: implications for delirium. Am J Geriatr Psychiatry 18:117-27
Jones, Richard N; Rudolph, James L; Inouye, Sharon K et al. (2010) Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision. J Clin Exp Neuropsychol 32:1041-9

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