Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
3K24DA000417-10S1
Application #
7632728
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Patel, Amrat
Project Start
1999-05-01
Project End
2010-03-31
Budget Start
2008-06-15
Budget End
2009-03-31
Support Year
10
Fiscal Year
2008
Total Cost
$9,139
Indirect Cost
Name
Washington University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Kharasch, Evan D (2017) Current Concepts in Methadone Metabolism and Transport. Clin Pharmacol Drug Dev 6:125-134
Horst, Jennifer; Frei-Jones, Melissa; Deych, Elena et al. (2016) Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. Pediatr Blood Cancer 63:2123-2130
Duma, Andreas; Cartmill, Christopher; Blood, Jane et al. (2015) The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesth Analg 120:1325-30
Kharasch, Evan D; Regina, Karen J; Blood, Jane et al. (2015) Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism. Anesthesiology 123:1142-53
Gadel, Sarah; Friedel, Christina; Kharasch, Evan D (2015) Differences in Methadone Metabolism by CYP2B6 Variants. Drug Metab Dispos 43:994-1001
Brier, Matthew R; Wu, Qian; Tanenbaum, Aaron B et al. (2015) Effect of HAART on Brain Organization and Function in HIV-Negative Subjects. J Neuroimmune Pharmacol 10:517-21
Meissner, Konrad; Blood, Jane; Francis, Amber M et al. (2014) Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics. Anesthesiology 121:1281-91
Campbell, Scott D; Regina, Karen J; Kharasch, Evan D (2014) Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay. J Biomol Screen 19:437-44
Sai, Kiran Kumar Solingapuram; Fan, Jinda; Tu, Zhude et al. (2014) Automated radiochemical synthesis and biodistribution of [¹¹C]l-?-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot 91:135-40
Kaspera, Rüdiger; Kirby, Brian J; Sahele, Tariku et al. (2014) Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochem Pharmacol 91:109-18

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