This application proposes Jean C. Beckham, Ph.D., for a K24 Mid-Career Investigator Award in Patient Oriented Research. Dr. Beckham is currently one of seven tenured women in the faculty of 413 at Duke University Medical Center Department of Psychiatry, and an accomplished PTSD and health researcher. Dr. Beckham demonstrates (a) her strong clinical research interest in co-morbid cigarette smoking and PTSD, (b) an outstanding research and clinical environment within Duke University Medical Center in which to conduct patient oriented research; (c) her unique position within the institution to nurture the careers of junior investigators, and (d) the need for protected research time to continue and expand these efforts. The K24 Mid-Career Investigator Award would permit Dr. Beckham to build on her previous program of patient-oriented research and training for clinical investigators, with a focus on smoking cessation and relapse prevention in PTSD and trauma-exposed smokers. Cigarette smoking is the number one avoidable cause of death and disability. Psychiatric patients consume 44% of all cigarettes. It is estimated that PTSD affects 2.6 million Americans, and that t .6 million of these patients are smokers. The chief aim of this proposal is to use time liberated by the Mid-Career Investigator Award in Patient-Oriented Research to increase the candidate's knowledge of several areas relevant to her future research and to develop, evaluate and disseminate new information on the treatment of smoking and PTSD. To this end, the career development plan increases the candidate's experience, knowledge, and skills in the following areas: 1) evidence-based smoking interventions for psychiatric populations; 2) statistics; and 3) intervention study design and methodology. The career development plan also proposes to: 1) increase awareness of the health effects of PTSD by educating professionals and the public, and 2) expand the candidate's mentoring of beginning investigators with the goal of attracting them to a career in patient-oriented research. This application's research plan focuses on two ongoing R-01 studies of PTSD, other ongoing research, and two proposed projects: 1) a CBT treatment component development for smoking cessation in PTSD (R-21 application) and an efficacy/effectiveness trial (R-01 application) to investigate optimal smoking cessation interventions for PTSD patients. In summary, this award would provide critical support for the candidate's career development, mentoring, and ongoing and new patient-oriented research on an understudied, relatively common, and severe co-morbid problem.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
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Fiscal Year
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Duke University
Schools of Medicine
United States
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Mitchell, John T; McIntyre, Elizabeth M; English, Joseph S et al. (2017) A Pilot Trial of Mindfulness Meditation Training for ADHD in Adulthood: Impact on Core Symptoms, Executive Functioning, and Emotion Dysregulation. J Atten Disord 21:1105-1120
Dennis, Paul A; Weinberg, J Brice; Calhoun, Patrick S et al. (2016) An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. J Psychosom Res 83:33-9
Carpenter, Vickie L; Hertzberg, Jeffrey S; Kirby, Angela C et al. (2015) Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans. J Clin Psychiatry 76:959-64
Liu, Yutao; Garrett, Melanie E; Dennis, Michelle F et al. (2015) An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. PLoS One 10:e0119998
Gentes, Emily; Dennis, Paul A; Kimbrel, Nathan A et al. (2015) Latent Factor Structure of DSM-5 Posttraumatic Stress Disorder. Psychopathol Rev 2:17-29
Oddone, Ania E; Dennis, Paul A; Calhoun, Patrick S et al. (2015) Orthostatic hypotension in young adults with and without posttraumatic stress disorder. Psychol Trauma 7:229-33
Vrana, Scott R; Calhoun, Patrick S; Dennis, Michelle F et al. (2015) Acoustic startle and prepulse inhibition predict smoking lapse in posttraumatic stress disorder. J Psychopharmacol 29:1070-6
Farris, Samantha G; Zvolensky, Michael J; Beckham, Jean C et al. (2014) Trauma exposure and cigarette smoking: the impact of negative affect and affect-regulatory smoking motives. J Addict Dis 33:354-65
Mitchell, John T; Dennis, Michelle F; English, Joseph S et al. (2014) Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder. Subst Use Misuse 49:1446-56
Dedert, Eric A; Dennis, Paul A; Swinkels, Cindy M et al. (2014) Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res 16:430-6

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