This is a competing renewal application for a K24 in patient-oriented research (POR) for Silva Arslanian, M.D. of the Children's Hospital University of Pittsburgh, School of Medicine. The applicant's original award provided support for POR for investigating insulin resistance during childhood growth and development, mentoring of junior faculty and fellows, advancing the research in new directions, and leadership in POR locally, nationally, and internationally. All of these aims have been executed with outstanding rigor, and the candidate has been successful in accomplishing the following: 1) Competitively renewed her R01 (2R01 HD027503);2) Obtained new independent NIH funding as PI (1U01 DK063704), and funding for several pharmaceutical trials;3) Advanced her mentoring commitment by obtaining new funding as PI for a felllow training grant (T32 DK63686) and junior faculty development grant (K12 DK63704), both in pediatric diabetes;4) Established new collaborations in POR at her own institution (1R01- HD38425, and 5U01 DK061230;PI, Marsha Marcus, Ph.D.) and with other academic institutions (1R01 DK071485;PI, Shumei Sun, Ph.D., Wright State University);5) Competitively renewed the GCRC grant (5M01RR00084), with an outstanding score, at Children's Hospital of Pittsburgh, where she is director;6) Became a board member of the Endocrine Fellows Foundation, a national organization whose primary and sole mission is the education and research support of endocrine fellows nationally;7) Increased the pool of pediatrician investigators in POR by attracting and mentoring new fellows/faculty from within and outside the institution;9) Assumed a leadership role in directing the newly founded Weight Management &Wellness Center (WMWC) at Children's Hospital of Pittsburgh;and, last but not least, received the inaugural University of Pittsburgh Medical Center Richard L. Day Endowed Chair in Pediatrics. This renewal application proposes to: 1) Continue the leadership of the PI in POR in the area of childhood obesity, insulin resistance, type 2 diabetes, and cardiovascular disease, major public health problems of this millennium;2) Provide ongoing mentoring to junior faculty, fellows, and medical students; and 3) To conduct innovative research in childhood insulin resistance, its causes, complications and control strategies. Support for these activities will enable Dr. Arslanian to further strengthen and expand the research scope of childhood obesity and insulin resistance but, more importantly, contribute to the academic development of young and upcoming clinician-investigators who will contribute to the global childhood obesity control by developing new paradigms of intervention, prevention and treatment.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Pediatrics Subcommittee (CHHD)
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Winer, Karen
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University of Pittsburgh
Schools of Medicine
United States
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Kim, Joon Young; Tfayli, Hala; Michaliszyn, Sara F et al. (2018) Impaired Lipolysis, Diminished Fat Oxidation, and Metabolic Inflexibility in Obese Girls With Polycystic Ovary Syndrome. J Clin Endocrinol Metab 103:546-554
Kim, Joon Young; Nasr, Alexis; Tfayli, Hala et al. (2017) Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired ?-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance. Diabetes 66:3085-3090
Kim, Joon Young; Tfayli, Hala; Michaliszyn, Sara F et al. (2017) Anti-Müllerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome. J Adolesc Health 60:333-339
Michaliszyn, Sara F; Lee, SoJung; Bacha, Fida et al. (2017) Differences in ?-cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role? Pediatr Diabetes 18:143-151
Kim, Joon Young; Michaliszyn, Sara F; Nasr, Alexis et al. (2016) The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth. Diabetes Care 39:1431-9
Kim, Joon Young; Tfayli, Hala; Michaliszyn, Sara F et al. (2016) Distinguishing characteristics of metabolically healthy versus metabolically unhealthy obese adolescent girls with polycystic ovary syndrome. Fertil Steril 105:1603-11
Hughan, Kara S; Tfayli, Hala; Warren-Ulanch, Julia G et al. (2016) Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome. J Pediatr 168:104-11.e1
Michaliszyn, Sara F; Mari, Andrea; Lee, SoJung et al. (2014) ?-cell function, incretin effect, and incretin hormones in obese youth along the span of glucose tolerance from normal to prediabetes to type 2 diabetes. Diabetes 63:3846-55
Burns, Stephen F; Lee, SoJung; Bacha, Fida et al. (2014) Pre-diabetes in overweight youth and early atherogenic risk. Metabolism 63:1528-35
Michaliszyn, Sara F; Lee, Sojung; Tfayli, Hala et al. (2013) Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile. Fertil Steril 100:1745-51

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