Menarche is the culmination of a series of central nervous system maturational events. In normal girls, the time course from menarche to the establishment of regular, ovulatory cycles is only partially studied. Prior studies have been limited by the need to use serial serum sampling and inadequate sampling frequencies to determine definitively whether or not ovulation occurs. Recent clinical research indicates that, in a population of normal young women, regular cycles are established relatively rapidly (i.e., within a year) of menarche. However, this and other studies have been unable to elucidate the patterns of menstrual cycling that occur up to and after the onset of menstruation. It is the broad goal of this proposal to describe the pattern(s) of reproductive hormones in normal girls at menarche and to determine the latency to regular, ovulatory cycling in normal perimenarcheal girls. This overall goal will be accomplished using the K24 award mechanism to develop further the career of the PI while providing mentorship, guidance and focus for a junior faculty member within the Department of Ob/Gyn and Women's Health at the Albert Einstein College of Medicine (AECOM). The three specific aims of the proposal are to: 1. Provide protected time for the PI to obtain formal training in epidemiology and biostatistics; 2. Undertake a mentored research experience for Dr. Staci Pollack, a junior faculty member in the Department of Ob/Gyn and Women's Health; and 3. Develop a new line of research that will address unanswered questions about the maturation of the hypothalamic-pituitary-axis in peripubertal girls.
These aims will be achieved concurrently by the enrollment of Dr. Santoro in the Clinical Research Training Program at the AECOM's epidemiology and biostatistics courses in Years one and two of the project period. At the time Dr. Santoro is acquiring this expertise, Dr. Pollack, her trainee and protege, will implement a study of perimenarcheal reproductive hormonal dynamics in a population of girls. Dr. Santoro will mentor Dr. Pollack in the laboratory techniques of field assessments of urinary hormone patterns and their analysis, an area in which she has experience and a substantial track record. Dr. Pollack and Dr. Santoro will complete the funding period with the development and initiation of preliminary data and study design sufficient to fund a larger clinical trial that will address some of the causes of reproductive endocrine abnormalities in perimenarcheal girls.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HD041978-05
Application #
7061762
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Parrott, Estella C
Project Start
2002-04-05
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
5
Fiscal Year
2006
Total Cost
$83,146
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Santoro, Nanette; Allshouse, Amanda; Neal-Perry, Genevieve et al. (2017) Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study. Menopause 24:238-246
Ross, Lauren A; Polotsky, Alex J; Kucherov, Alexander et al. (2014) Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring) 22:1464-9
Roth, Lauren W; Allshouse, Amanda A; Lesh, Jennifer et al. (2013) The correlation between self-reported and measured height, weight, and BMI in reproductive age women. Maturitas 76:185-8
Traub, Michael L; Jain, Akas; Maslow, Bat-Sheva et al. (2012) The ""muffin test""--an alternative to the oral glucose tolerance test for detecting impaired glucose tolerance. Menopause 19:62-6
Karmon, Anatte; Hailpern, Susan M; Neal-Perry, Genevieve et al. (2011) Association of ethnicity with involuntary childlessness and perceived reasons for infertility: baseline data from the Study of Women's Health Across the Nation (SWAN). Fertil Steril 96:1200-5.e1
Kucherov, Alexander; Polotsky, Alex J; Menke, Marie et al. (2011) Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril 95:2063-6
Butler, Laura; Santoro, Nanette (2011) The reproductive endocrinology of the menopausal transition. Steroids 76:627-35
Zhang, Katie; Zeitlian, Gohar; Adel, Goli et al. (2011) Enhanced hypothalamic-pituitary sensitivity to estrogen in premenopausal women with diminished ovarian reserve compared with older perimenopausal controls. Menopause 18:880-5
Relwani, Rachna; Berger, Dara; Santoro, Nanette et al. (2011) Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci 18:391-7
Keltz, Julia; Zapantis, Athena; Jindal, Sangita K et al. (2010) Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet 27:539-44

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