This study will examine the interaction between Cyclosporin (CyA), renal function, EDRF, and endothelin via infusion of L-arginine in normal subjects, CyA-treated renal allograft recipients, & transplant subjects not on CyA. We postulate that L-arginine will stimulate endothelial production of EDRF, resulting in amelioration of CyA nephrotoxicity.

Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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