PNU-214936 a Fab fragment directed against a glycoprotein 5T4 chemically linked to a mutated superantigen. This study utilized a 3 hours daily X 4 infusion. Patients could receive a second course if not precluded by disease progression, toxicity or immune response. The principal toxicities were fever, local inflammatory reaction, chills during or shortly after the treatment. No responses were observed in 17 treated patients.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
40
Fiscal Year
2000
Total Cost
$59,058
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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