This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Genital herpes is common in the U.S. affecting over 22% of all sexually active adults. The infection is incurable and places individuals at risk for substantial physical and mental health morbidity, as well as places infants born to infected mothers at risk for acquisition of congenital infections. Recent preliminary studies suggest that a glycoprotein vaccine developed by GlaxoSmithKline (GSK) reduces susceptibility to genital herpes in females who have not had prior infections due to Herpes simplex virus (HSV) type 1 or 2. We propose to conduct a NIH-sponsored Phase III controlled trial of a prototype HSV vaccine for prevention of genital herpes in females 18-30 years of age who are seronegative for antibodies and, if seronegative will be eligible for enrollment. Participants will receive 3 injections of the prototype vaccine, or for comparison, hepatitis A vaccine at months 0, 1, and 6 and be followed for serologic or microbiologic evidence of infection over a period of 20 months. At the UAB site we anticipate the need to screen over 3000 candidates in order to enroll 500 participants for vaccination and follow-up.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000032-46
Application #
7380421
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-03-01
Project End
2007-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
46
Fiscal Year
2006
Total Cost
$185,183
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Yu, Alan S L; Shen, Chengli; Landsittel, Douglas P et al. (2018) Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int 93:691-699
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Kline, Timothy L; Korfiatis, Panagiotis; Edwards, Marie E et al. (2017) Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease. Kidney Int 92:1206-1216
James, Jennifer; Munson, David; DeMauro, Sara B et al. (2017) Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr 190:118-123.e4
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