This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of obesity is rising dramatically. As the number of obese people increases, so do the complications associated with obesity. In recent years it has been discovered that adipose tissue plays a key role in the pathogenesis of obesity and T2DM. Adiponectin is an adipocytokine that may be one of the key contributors. This study hopes to evaluate adiponectin levels and insulin resistance in both AA and CA with T2DM before and after gastric bypass surgery. This will be accomplished by measuring adiponectin, glucose, CRP, HbA1c, IL-6 and TNF-alpha levels in subjects before and after gastric bypass surgery. Homeostasis model assessment (HOMA) insulin resistance (IR) will be determined. The HOMA -IR is a formula used to approximate insulin resistance. Forty-five subjects, 10 African American (AA) and 35 Caucasian American (CA) subjects, will be recruited. Informed consent will be obtained. The presence of significant ethnic differences in adiponectin levels may be one of the reasons that complications of T2DM vary between AA and CA. Furthermore, differences in adiponectin levels and insulin resistance before and after gastric bypass may help determine which patients are most likely to benefit from gastric bypass surgery.
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