This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We hypothesize that gentamicin given over six months will significantly improve strength in DMD patients. Thirteen percent of DMD patients have a stop codon mutation based on our mutational analysis of 141 non-deleted patients.13 To fulfill its potential as a long-term therapeutic agent for DMD, gentamicin must be safe and improve muscle strength. The primary goal of this study will be to determine the safety of gentamicin over six months. The premise for the six-month study proposed here is that the serum CK reduction was an early indicator of membrane stability in previous trials. Therefore, long-term administration will permit amplification of dystrophin expression. Measurable amounts of dystrophin should be detected at the sarcolemma protecting the muscle from necrosis, while at the same time increasing muscle strength.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000034-47
Application #
7625457
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-23
Project End
2007-11-30
Budget Start
2007-04-23
Budget End
2007-11-30
Support Year
47
Fiscal Year
2007
Total Cost
$105,399
Indirect Cost
Name
Ohio State University
Department
Administration
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Beversdorf, David Q; Carpenter, Allen L; Alexander, Jessica K et al. (2018) Influence of Serotonin Transporter SLC6A4 Genotype on the Effect of Psychosocial Stress on Cognitive Performance: An Exploratory Pilot Study. Cogn Behav Neurol 31:79-85
Tita, Alan T N; Lai, Yinglei; Landon, Mark B et al. (2017) Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. Am J Perinatol 34:1464-1469
Criado, Kristen K; Sharp, William G; McCracken, Courtney E et al. (2017) Overweight and obese status in children with autism spectrum disorder and disruptive behavior. Autism :1362361316683888
Lee, Kyoung Suk; Lennie, Terry A; Yoon, Ju Young et al. (2017) Living Arrangements Modify the Relationship Between Depressive Symptoms and Self-care in Patients With Heart Failure. J Cardiovasc Nurs 32:171-179
Landon, Mark B; Grobman, William A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network (2016) What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry. Semin Perinatol 40:281-6
Blackwell, Sean C; Landon, Mark B; Mele, Lisa et al. (2016) Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus. Obstet Gynecol 128:1325-1332
Navari, Rudolph M; Qin, Rui; Ruddy, Kathryn J et al. (2016) Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting. N Engl J Med 375:134-42
Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7
Harper, Lorie M; Mele, Lisa; Landon, Mark B et al. (2016) Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes. Obstet Gynecol 127:893-8
Kirkby, Stephen E; Hayes Jr, Don; Parsons, Jonathan P et al. (2015) Eucapnic Voluntary Hyperventilation to Detect Exercise-Induced Bronchoconstriction in Cystic Fibrosis. Lung 193:733-8

Showing the most recent 10 out of 426 publications