This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary goal of this study is to determine the relationship between psychosocial factors (stress, social support, and mood) and markers of inflammation (including cervico-vaginal IL-6, serum IL-6, and serum IL-6 soluble receptor) in pregnant women at baseline and following influenza vaccination. The secondary goal is to assess how the same psychosocial factors relate to baseline and post-vaccine influenza antibody titers in pregnant women. The American College of Obstetrics and Gynecology recommends that pregnant women receive the influenza vaccine during influenza season (October and Mid-May). We are approved by the IRB to enroll up to 175 pregnant women. However, we plan to enroll only 52 participants for this study. Participants will be enrolled between the months of October and Mid-May. At the baseline visit (Visit 0) each participant will receive an influenza vaccination. A battery of psychosocial questionnaires will be collected that include information on negative or upsetting social experiences, general social support, depressive symptoms, perceived stress, anxiety, loneliness, attitudes regarding happiness about pregnancy, and subjective socioeconomic status. This information will be obtained at time of vaccination, 1-2 weeks and 2-5 weeks post-vaccine. Blood samples and cervicovaginal fluid by way of venipuncture and cervicovaginal swab will also be obtained for measurement of interleukin-6 levels at time of vaccination, and approximately 1-2 weeks and 2-5 weeks post-vaccine. Cord blood will also be obtained from the discarded umbilical cord for measurement of interleukin-6 at time of delivery.
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