Abstract

Patients with recurring VT/VF are admitted to the CRC where antiarrhythmia (AA) drugs are tested for improvement in ventricular arrhythmia complexity and frequency. When (AA) drugs are judged not efficacous, placement of an Automatic Implantable Cardioverter/Defribrillator (AICD) is recommended. After informed consent, a subgroup of (AICD) patients are randomly allocated to amiodarone or placebo in a prospective, randomized double- blind clinical trial.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000035-30A1
Application #
3882801
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
30
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Kullmann, F Aura; Katofiasc, M; Thor, K B et al. (2017) Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4-10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats. Naunyn Schmiedebergs Arch Pharmacol 390:163-173
Mercadante, Courtney J; Herrera, Carolina; Pettiglio, Michael A et al. (2016) The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats. Biometals 29:417-22
Doria-Rose, V Paul; Marcus, Pamela M; Miller, Anthony B et al. (2010) Does the source of death information affect cancer screening efficacy results? A study of the use of mortality review versus death certificates in four randomized trials. Clin Trials 7:69-77
Doria-Rose, V Paul; Marcus, Pamela M; Szabo, Eva et al. (2009) Randomized controlled trials of the efficacy of lung cancer screening by sputum cytology revisited: a combined mortality analysis from the Johns Hopkins Lung Project and the Memorial Sloan-Kettering Lung Study. Cancer 115:5007-17
Holbrook, Janet T; Jabs, Douglas A; Weinberg, David V et al. (2003) Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. Arch Ophthalmol 121:99-107
Becker, D M; Tuggle, M B; Prentice, M F (2001) Building a gateway to promote cardiovascular health research in African American communities: lessons and findings from the field. Am J Med Sci 322:276-81
Holbrook, J T; Meinert, C L; Jabs, D A et al. (2001) Patient notification and follow-up after suspension of treatment protocols. experience from four clinical trials of treatments for AIDS-related CMV retinitis. Control Clin Trials 22:62-8
Kral, B G; Becker, L C; Yook, R M et al. (2001) Racial differences in low-density lipoprotein particle size in families at high risk for premature coronary heart disease. Ethn Dis 11:325-37
Becker, D M; Tuggle, M B; Prentice, M F (2001) Building a gateway to promote cardiovascular health research in African-American communities: lessons and findings from the field. Am J Med Sci 322:288-93
Holbrook, J T; Meinert, C L; Van Natta, M L et al. (2001) Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients. Arch Ophthalmol 119:554-63

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