Abstract

The primary objective of this study is to describe the pharmacokinetics of oral ganciclovir in HIV+ subjects with varying degrees of renal function using an algorithm derived from similar studies in a solid organ transplant recipient study and to compare 3, 4.5 and 6 gram/day regimes to assess dose proportionality.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000035-36
Application #
2349336
Study Section
Project Start
Project End
Budget Start
1995-10-01
Budget End
1996-09-30
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Kullmann, F Aura; Katofiasc, M; Thor, K B et al. (2017) Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4-10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats. Naunyn Schmiedebergs Arch Pharmacol 390:163-173
Mercadante, Courtney J; Herrera, Carolina; Pettiglio, Michael A et al. (2016) The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats. Biometals 29:417-22
Doria-Rose, V Paul; Marcus, Pamela M; Miller, Anthony B et al. (2010) Does the source of death information affect cancer screening efficacy results? A study of the use of mortality review versus death certificates in four randomized trials. Clin Trials 7:69-77
Doria-Rose, V Paul; Marcus, Pamela M; Szabo, Eva et al. (2009) Randomized controlled trials of the efficacy of lung cancer screening by sputum cytology revisited: a combined mortality analysis from the Johns Hopkins Lung Project and the Memorial Sloan-Kettering Lung Study. Cancer 115:5007-17
Holbrook, Janet T; Jabs, Douglas A; Weinberg, David V et al. (2003) Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. Arch Ophthalmol 121:99-107
Martin, B K; Kaplan Gilpin, A M; Jabs, D A et al. (2001) Reliability, validity, and responsiveness of general and disease-specific quality of life measures in a clinical trial for cytomegalovirus retinitis. J Clin Epidemiol 54:376-86
Becker, D M; Tuggle, M B; Prentice, M F (2001) Building a gateway to promote cardiovascular health research in African American communities: lessons and findings from the field. Am J Med Sci 322:276-81
Holbrook, J T; Meinert, C L; Jabs, D A et al. (2001) Patient notification and follow-up after suspension of treatment protocols. experience from four clinical trials of treatments for AIDS-related CMV retinitis. Control Clin Trials 22:62-8
Kral, B G; Becker, L C; Yook, R M et al. (2001) Racial differences in low-density lipoprotein particle size in families at high risk for premature coronary heart disease. Ethn Dis 11:325-37
Becker, D M; Tuggle, M B; Prentice, M F (2001) Building a gateway to promote cardiovascular health research in African-American communities: lessons and findings from the field. Am J Med Sci 322:288-93

Showing the most recent 10 out of 65 publications